TY - GEN
T1 - Developing biomimetic collagen-based matrix using cyclodextrin for corneal repair
AU - Guo, Qiongyu
AU - Shores, Lucas
AU - Schein, Oliver
AU - Trexler, Morgana M.
AU - Elisseeff, Jennifer H.
N1 - Publisher Copyright:
© 2014 IEEE.
PY - 2014/12/2
Y1 - 2014/12/2
N2 - The worldwide demand for corneal transplantations cannot match by the supply of donor corneas, especially in most developing countries. There is a large need of developing new corneal substitute mimicking the native cornea in terms of optical, biomechanical and biological properties. The cornea has four main types of proteoglycan that play a critical role in collagen fibrogenesis and transparency. However, obtaining purified proteoglycans has been a challenging task due to their high cost. In this study, we employed cyclodextrins as a proteoglycan substitute to engineer a biomimetic collagen-based matrix. The incorporation of cyclodextrin in collagen membrane increased collagen thermal stability and reduced collagen fibrogenesis. As a result, a thick, transparent and mechanically strong collagen-based membrane was formed. This cyclodextrin-collagen membrane holds a great potential to be used as a therapeutic eye patch for corneal repair.
AB - The worldwide demand for corneal transplantations cannot match by the supply of donor corneas, especially in most developing countries. There is a large need of developing new corneal substitute mimicking the native cornea in terms of optical, biomechanical and biological properties. The cornea has four main types of proteoglycan that play a critical role in collagen fibrogenesis and transparency. However, obtaining purified proteoglycans has been a challenging task due to their high cost. In this study, we employed cyclodextrins as a proteoglycan substitute to engineer a biomimetic collagen-based matrix. The incorporation of cyclodextrin in collagen membrane increased collagen thermal stability and reduced collagen fibrogenesis. As a result, a thick, transparent and mechanically strong collagen-based membrane was formed. This cyclodextrin-collagen membrane holds a great potential to be used as a therapeutic eye patch for corneal repair.
KW - collagen
KW - corneal regeneration
KW - cyclodextrin
KW - fibrogenesis
KW - proteoglycan
UR - http://www.scopus.com/inward/record.url?scp=84940704259&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84940704259&partnerID=8YFLogxK
U2 - 10.1109/NEBEC.2014.6972807
DO - 10.1109/NEBEC.2014.6972807
M3 - Conference contribution
AN - SCOPUS:84940704259
T3 - Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC
BT - Proceedings - 2014 40th Annual Northeast Bioengineering Conference, NEBEC 2014
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2014 40th Annual Northeast Bioengineering Conference, NEBEC 2014
Y2 - 25 April 2014 through 27 April 2014
ER -