Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells

Kaitlyn Sadtler; Kenneth Estrellas; Brian W. Allen; Matthew T. Wolf; Hongni Fan; Ada J. Tam; Chirag H. Patel; Brandon S. Luber; Hao Wang; Kathryn R. Wagner; Jonathan D. Powell; Franck Housseau; Drew M. Pardoll; Jennifer H. Elisseeff

doi:10.1126/science.aad9272

Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells

Kaitlyn Sadtler, Kenneth Estrellas, Brian W. Allen, Matthew T. Wolf, Hongni Fan, Ada J. Tam, Chirag H. Patel, Brandon S. Luber, Hao Wang, Kathryn R. Wagner, Jonathan D. Powell, Franck Housseau, Drew M. Pardoll, Jennifer H. Elisseeff

Research output: Contribution to journal › Article › peer-review

235 Scopus citations

Abstract

Immune-mediated tissue regeneration driven by a biomaterial scaffold is emerging as an innovative regenerative strategy to repair damaged tissues. We investigated how biomaterial scaffolds shape the immune microenvironment in traumatic muscle wounds to improve tissue regeneration. The scaffolds induced a pro-regenerative response, characterized by an mTOR/Rictor-dependent T helper 2 pathway that guides interleukin-4-dependent macrophage polarization, which is critical for functional muscle recovery. Manipulating the adaptive immune system using biomaterials engineering may support the development of therapies that promote both systemic and local pro-regenerative immune responses, ultimately stimulating tissue repair.

Original language	English (US)
Pages (from-to)	366-370
Number of pages	5
Journal	Science
Volume	352
Issue number	6283
DOIs	https://doi.org/10.1126/science.aad9272
State	Published - Apr 15 2016

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title = "Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells",

abstract = "Immune-mediated tissue regeneration driven by a biomaterial scaffold is emerging as an innovative regenerative strategy to repair damaged tissues. We investigated how biomaterial scaffolds shape the immune microenvironment in traumatic muscle wounds to improve tissue regeneration. The scaffolds induced a pro-regenerative response, characterized by an mTOR/Rictor-dependent T helper 2 pathway that guides interleukin-4-dependent macrophage polarization, which is critical for functional muscle recovery. Manipulating the adaptive immune system using biomaterials engineering may support the development of therapies that promote both systemic and local pro-regenerative immune responses, ultimately stimulating tissue repair.",

author = "Kaitlyn Sadtler and Kenneth Estrellas and Allen, {Brian W.} and Wolf, {Matthew T.} and Hongni Fan and Tam, {Ada J.} and Patel, {Chirag H.} and Luber, {Brandon S.} and Hao Wang and Wagner, {Kathryn R.} and Powell, {Jonathan D.} and Franck Housseau and Pardoll, {Drew M.} and Elisseeff, {Jennifer H.}",

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doi = "10.1126/science.aad9272",

language = "English (US)",

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T1 - Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells

AU - Sadtler, Kaitlyn

AU - Estrellas, Kenneth

AU - Allen, Brian W.

AU - Wolf, Matthew T.

AU - Fan, Hongni

AU - Tam, Ada J.

AU - Patel, Chirag H.

AU - Luber, Brandon S.

AU - Wang, Hao

AU - Wagner, Kathryn R.

AU - Powell, Jonathan D.

AU - Housseau, Franck

AU - Pardoll, Drew M.

AU - Elisseeff, Jennifer H.

PY - 2016/4/15

Y1 - 2016/4/15

N2 - Immune-mediated tissue regeneration driven by a biomaterial scaffold is emerging as an innovative regenerative strategy to repair damaged tissues. We investigated how biomaterial scaffolds shape the immune microenvironment in traumatic muscle wounds to improve tissue regeneration. The scaffolds induced a pro-regenerative response, characterized by an mTOR/Rictor-dependent T helper 2 pathway that guides interleukin-4-dependent macrophage polarization, which is critical for functional muscle recovery. Manipulating the adaptive immune system using biomaterials engineering may support the development of therapies that promote both systemic and local pro-regenerative immune responses, ultimately stimulating tissue repair.

AB - Immune-mediated tissue regeneration driven by a biomaterial scaffold is emerging as an innovative regenerative strategy to repair damaged tissues. We investigated how biomaterial scaffolds shape the immune microenvironment in traumatic muscle wounds to improve tissue regeneration. The scaffolds induced a pro-regenerative response, characterized by an mTOR/Rictor-dependent T helper 2 pathway that guides interleukin-4-dependent macrophage polarization, which is critical for functional muscle recovery. Manipulating the adaptive immune system using biomaterials engineering may support the development of therapies that promote both systemic and local pro-regenerative immune responses, ultimately stimulating tissue repair.

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Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells

Abstract

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