Detonation nanodiamond toxicity in human airway epithelial cells is modulated by air oxidation

Robert Silbajoris, William Linak, Olga Shenderova, Christopher Winterrowd, Huan Cheng Chang, Jay L. Zweier, Anirudh Kota, Lisa A. Dailey, Nicholas Nunn, Philip A. Bromberg, James M. Samet

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Detonation nanodiamonds (DNDs), a nanomaterial with an increasing range of industrial and biomedical applications, have previously been shown to induce a pro-inflammatory response in cultured human airway epithelial cells (HAECs). We now show that surface modifications induced by air oxidation of DND (AO-DND), including an increase in oxygen content, formation of carboxylic groups associated with the appearance of high negative zeta potential and a decrease in unpaired electron content, are accompanied by a significant loss of bioactivity, as measured by levels of interleukin-8 mRNA in HAEC. These findings are relevant to the identification of chemical determinants and molecular mechanisms of the inhalational toxicity of carbonaceous nanomaterials.

Original languageEnglish (US)
Pages (from-to)16-23
Number of pages8
JournalDiamond and Related Materials
StatePublished - May 30 2015
Externally publishedYes


  • Human airway epithelial cells
  • Interleukin-8
  • Nanodiamond
  • Toxicity
  • Zeta potential

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Materials Chemistry
  • Electrical and Electronic Engineering
  • Mechanical Engineering
  • Physics and Astronomy(all)
  • Chemistry(all)


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