Determining the optimal carbapenem MIC that distinguishes carbapenemase-producing and non-carbapenemase-producing carbapenem-resistant Enterobacteriaceae

Pranita D. Tamma; Yanjie Huang; Belita N.A. Opene; Patricia J. Simner

doi:10.1128/AAC.00838-16

Determining the optimal carbapenem MIC that distinguishes carbapenemase-producing and non-carbapenemase-producing carbapenem-resistant Enterobacteriaceae

Pranita D. Tamma, Yanjie Huang, Belita N.A. Opene, Patricia J. Simner

School of Medicine

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Carbapenemase-producing (CP) Enterobacteriaceae are largely responsible for the rapid spread of carbapenem-resistant Enterobacteriaceae (CRE). Distinguishing CP-CRE from non-CP-CRE has important infection control implications. In a cohort of 198 CRE isolates, for isolates that remained susceptible or intermediate to some carbapenem antibiotics, an ertapenem MIC of 0.5μ g/ml and meropenem, imipenem, and doripenem MICs of 2μ g/ml were best able to distinguish CP-CRE from non-CP-CRE isolates.

Original language	English (US)
Pages (from-to)	6425-6429
Number of pages	5
Journal	Antimicrobial agents and chemotherapy
Volume	60
Issue number	10
DOIs	https://doi.org/10.1128/AAC.00838-16
State	Published - Oct 2016

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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abstract = "Carbapenemase-producing (CP) Enterobacteriaceae are largely responsible for the rapid spread of carbapenem-resistant Enterobacteriaceae (CRE). Distinguishing CP-CRE from non-CP-CRE has important infection control implications. In a cohort of 198 CRE isolates, for isolates that remained susceptible or intermediate to some carbapenem antibiotics, an ertapenem MIC of 0.5μ g/ml and meropenem, imipenem, and doripenem MICs of 2μ g/ml were best able to distinguish CP-CRE from non-CP-CRE isolates.",

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AU - Opene, Belita N.A.

AU - Simner, Patricia J.

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AB - Carbapenemase-producing (CP) Enterobacteriaceae are largely responsible for the rapid spread of carbapenem-resistant Enterobacteriaceae (CRE). Distinguishing CP-CRE from non-CP-CRE has important infection control implications. In a cohort of 198 CRE isolates, for isolates that remained susceptible or intermediate to some carbapenem antibiotics, an ertapenem MIC of 0.5μ g/ml and meropenem, imipenem, and doripenem MICs of 2μ g/ml were best able to distinguish CP-CRE from non-CP-CRE isolates.

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Determining the optimal carbapenem MIC that distinguishes carbapenemase-producing and non-carbapenemase-producing carbapenem-resistant Enterobacteriaceae

Abstract

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