TY - JOUR
T1 - Determinants of urinary 1-hydroxypyrene glucuronide in South Korean children
AU - Lee, Kyoung Ho
AU - Vermeulen, Roel
AU - Lenters, Virissa
AU - Cho, Soo Hun
AU - Kang, Daehee
AU - Strickland, Paul T.
N1 - Funding Information:
Acknowledgments This study was supported by a grant of The Korea Health 21 R&D Project, from the Ministry of Health and Welfare, (02-PJ1-PG1-CH03-0001), and by the Ministry of Environment of the Republic of Korea, as The Eco-technopia 21 Project.
Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2009
Y1 - 2009
N2 - Objectives: This study was conducted to investigate the dominant sources of the urinary pyrene metabolite, 1-hydroxypyrene glucuronide (1-OHPG), in South Korean children. Methods: Urine samples were collected from 102 non-smoking children (aged 10-14). Urinary 1-OHPG was assayed by synchronous fluorescence spectroscopy, following immuno-affinity purification using monoclonal antibody 8E11. Urinary cotinine, a metabolite of nicotine, was measured by GC/MS. Information on environmental tobacco smoke (ETS) exposure, diet, fuel type for heating home, and other possible sources of PAH exposure was collected by self-administered questionnaires. Results: Mean (±SE) 1-OHPG levels were 1.64 (±0.06) ng/ml (range 0.04-3.27 ng/ml). Two multiple linear regression analyses (differing in how ETS was approximated: by parental smoking or urinary cotinine) revealed a positive association between urinary 1-OHPG levels and parental smoking at home (P = 0.007), log urinary cotinine (P = 0.165), frequent grilled (shell)fish consumption (P = 0.061), and living in a commercial/other zone (P = 0.007) versus a residential or industrial zone. No consistent associations were found between 1-OHPG and the child's sex, grilled meat consumption, or fuels used to heat the home. Conclusions: These results support that ETS, frequent grilled fish consumption, and the ambient environment are important predictors of urinary 1-OHPG levels in South Korean children.
AB - Objectives: This study was conducted to investigate the dominant sources of the urinary pyrene metabolite, 1-hydroxypyrene glucuronide (1-OHPG), in South Korean children. Methods: Urine samples were collected from 102 non-smoking children (aged 10-14). Urinary 1-OHPG was assayed by synchronous fluorescence spectroscopy, following immuno-affinity purification using monoclonal antibody 8E11. Urinary cotinine, a metabolite of nicotine, was measured by GC/MS. Information on environmental tobacco smoke (ETS) exposure, diet, fuel type for heating home, and other possible sources of PAH exposure was collected by self-administered questionnaires. Results: Mean (±SE) 1-OHPG levels were 1.64 (±0.06) ng/ml (range 0.04-3.27 ng/ml). Two multiple linear regression analyses (differing in how ETS was approximated: by parental smoking or urinary cotinine) revealed a positive association between urinary 1-OHPG levels and parental smoking at home (P = 0.007), log urinary cotinine (P = 0.165), frequent grilled (shell)fish consumption (P = 0.061), and living in a commercial/other zone (P = 0.007) versus a residential or industrial zone. No consistent associations were found between 1-OHPG and the child's sex, grilled meat consumption, or fuels used to heat the home. Conclusions: These results support that ETS, frequent grilled fish consumption, and the ambient environment are important predictors of urinary 1-OHPG levels in South Korean children.
KW - 1-Hydroxypyrene glucuronide
KW - Children
KW - Cotinine
KW - Diet
KW - Environmental tobacco smoke
KW - Polycyclic aromatic hydrocarbons
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U2 - 10.1007/s00420-008-0385-2
DO - 10.1007/s00420-008-0385-2
M3 - Article
C2 - 19020893
AN - SCOPUS:68449093403
SN - 0340-0131
VL - 82
SP - 961
EP - 968
JO - International Archives of Occupational and Environmental Health
JF - International Archives of Occupational and Environmental Health
IS - 8
ER -