Determinants of urinary 1-hydroxypyrene glucuronide in South Korean children

Kyoung Ho Lee, Roel Vermeulen, Virissa Lenters, Soo Hun Cho, Daehee Kang, Paul T. Strickland

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Objectives: This study was conducted to investigate the dominant sources of the urinary pyrene metabolite, 1-hydroxypyrene glucuronide (1-OHPG), in South Korean children. Methods: Urine samples were collected from 102 non-smoking children (aged 10-14). Urinary 1-OHPG was assayed by synchronous fluorescence spectroscopy, following immuno-affinity purification using monoclonal antibody 8E11. Urinary cotinine, a metabolite of nicotine, was measured by GC/MS. Information on environmental tobacco smoke (ETS) exposure, diet, fuel type for heating home, and other possible sources of PAH exposure was collected by self-administered questionnaires. Results: Mean (±SE) 1-OHPG levels were 1.64 (±0.06) ng/ml (range 0.04-3.27 ng/ml). Two multiple linear regression analyses (differing in how ETS was approximated: by parental smoking or urinary cotinine) revealed a positive association between urinary 1-OHPG levels and parental smoking at home (P = 0.007), log urinary cotinine (P = 0.165), frequent grilled (shell)fish consumption (P = 0.061), and living in a commercial/other zone (P = 0.007) versus a residential or industrial zone. No consistent associations were found between 1-OHPG and the child's sex, grilled meat consumption, or fuels used to heat the home. Conclusions: These results support that ETS, frequent grilled fish consumption, and the ambient environment are important predictors of urinary 1-OHPG levels in South Korean children.

Original languageEnglish (US)
Pages (from-to)961-968
Number of pages8
JournalInternational Archives of Occupational and Environmental Health
Issue number8
StatePublished - 2009


  • 1-Hydroxypyrene glucuronide
  • Children
  • Cotinine
  • Diet
  • Environmental tobacco smoke
  • Polycyclic aromatic hydrocarbons

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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