Determinants of recent aflatoxin exposure among pregnant women in rural Zimbabwe

Laura E. Smith; Mduduzi N.N. Mbuya; Andrew J. Prendergast; Paul C. Turner; Sandra Ruboko; Jean H. Humphrey; Rebecca J. Nelson; Ancikaria Chigumira; George Kembo; Rebecca J. Stoltzfus

doi:10.1002/mnfr.201601049

Determinants of recent aflatoxin exposure among pregnant women in rural Zimbabwe

Laura E. Smith, Mduduzi N.N. Mbuya, Andrew J. Prendergast, Paul C. Turner, Sandra Ruboko, Jean H. Humphrey, Rebecca J. Nelson, Ancikaria Chigumira, George Kembo, Rebecca J. Stoltzfus

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Scope: Aflatoxins (AFs) are toxic secondary metabolites of Aspergillus species that contaminate staple foods such as maize and groundnuts. AF exposure during pregnancy has been associated with adverse birth outcomes in limited-scale surveys in sub-Saharan Africa. The objective of this study was to describe the determinants of AF exposure, using urinary aflatoxin M1 (AFM1) biomarkers and data generated by the Sanitation Hygiene Infant Nutrition Efficacy (SHINE) trial for rural Zimbabwean women in early pregnancy. Sanitation Hygiene Infant Nutrition Efficacy is a large, cluster-randomized community-based trial in Zimbabwe designed to investigate the independent and combined effects of nutrition and hygiene interventions on early child growth. Methods and results: Urine samples collected from 1580 pregnant women in rural Zimbabwe at median gestational age of 13.9 wk were measured for AFM1. AFM1 was detected in 30% of samples (median of exposed, 162 pg AFM1/mg creatinine; range 30–6046 pg AFM1/mg). In multivariable ordinal logistic models, geographical location (p<0.001), seasonality (p < 0.001) and dietary practices (p = 0.011) were significant predictors of urinary AFM1. Conclusion: This is the largest AF biomarker survey conducted in Zimbabwe, and demonstrated frequent exposure in pregnant women with clear temporal and spatial variability in AF biomarker levels.

Original language	English (US)
Article number	1601049
Journal	Molecular Nutrition and Food Research
Volume	61
Issue number	9
DOIs	https://doi.org/10.1002/mnfr.201601049
State	Published - Sep 2017

Keywords

Aflatoxin
Dietary diversity
Pregnancy
Spatial variation
Temporal variation

ASJC Scopus subject areas

Biotechnology
Food Science

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10.1002/mnfr.201601049

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@article{3a62a0000f1441b39ea5b34a1d646b73,

title = "Determinants of recent aflatoxin exposure among pregnant women in rural Zimbabwe",

abstract = "Scope: Aflatoxins (AFs) are toxic secondary metabolites of Aspergillus species that contaminate staple foods such as maize and groundnuts. AF exposure during pregnancy has been associated with adverse birth outcomes in limited-scale surveys in sub-Saharan Africa. The objective of this study was to describe the determinants of AF exposure, using urinary aflatoxin M1 (AFM1) biomarkers and data generated by the Sanitation Hygiene Infant Nutrition Efficacy (SHINE) trial for rural Zimbabwean women in early pregnancy. Sanitation Hygiene Infant Nutrition Efficacy is a large, cluster-randomized community-based trial in Zimbabwe designed to investigate the independent and combined effects of nutrition and hygiene interventions on early child growth. Methods and results: Urine samples collected from 1580 pregnant women in rural Zimbabwe at median gestational age of 13.9 wk were measured for AFM1. AFM1 was detected in 30% of samples (median of exposed, 162 pg AFM1/mg creatinine; range 30–6046 pg AFM1/mg). In multivariable ordinal logistic models, geographical location (p<0.001), seasonality (p < 0.001) and dietary practices (p = 0.011) were significant predictors of urinary AFM1. Conclusion: This is the largest AF biomarker survey conducted in Zimbabwe, and demonstrated frequent exposure in pregnant women with clear temporal and spatial variability in AF biomarker levels.",

keywords = "Aflatoxin, Dietary diversity, Pregnancy, Spatial variation, Temporal variation",

author = "Smith, {Laura E.} and Mbuya, {Mduduzi N.N.} and Prendergast, {Andrew J.} and Turner, {Paul C.} and Sandra Ruboko and Humphrey, {Jean H.} and Nelson, {Rebecca J.} and Ancikaria Chigumira and George Kembo and Stoltzfus, {Rebecca J.}",

note = "Funding Information: We are grateful to our funders who supported this work including: USDA NIFA Pre-doctoral Fellowship (2013-67011-21116) and Cornell Atkinson Center for a Sustainable Future Academic Venture Fund. AJP is funded by the Wellcome Trust (108065/Z/15/Z). We acknowledge the support of the Zimbabwean Ministry of Health and Child Care for making this research possible. Publisher Copyright: {\textcopyright} 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",

year = "2017",

month = sep,

doi = "10.1002/mnfr.201601049",

language = "English (US)",

volume = "61",

journal = "Molecular Nutrition and Food Research",

issn = "1613-4125",

publisher = "Wiley-VCH Verlag",

number = "9",

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TY - JOUR

T1 - Determinants of recent aflatoxin exposure among pregnant women in rural Zimbabwe

AU - Smith, Laura E.

AU - Mbuya, Mduduzi N.N.

AU - Prendergast, Andrew J.

AU - Turner, Paul C.

AU - Ruboko, Sandra

AU - Humphrey, Jean H.

AU - Nelson, Rebecca J.

AU - Chigumira, Ancikaria

AU - Kembo, George

AU - Stoltzfus, Rebecca J.

N1 - Funding Information: We are grateful to our funders who supported this work including: USDA NIFA Pre-doctoral Fellowship (2013-67011-21116) and Cornell Atkinson Center for a Sustainable Future Academic Venture Fund. AJP is funded by the Wellcome Trust (108065/Z/15/Z). We acknowledge the support of the Zimbabwean Ministry of Health and Child Care for making this research possible. Publisher Copyright: © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

PY - 2017/9

Y1 - 2017/9

N2 - Scope: Aflatoxins (AFs) are toxic secondary metabolites of Aspergillus species that contaminate staple foods such as maize and groundnuts. AF exposure during pregnancy has been associated with adverse birth outcomes in limited-scale surveys in sub-Saharan Africa. The objective of this study was to describe the determinants of AF exposure, using urinary aflatoxin M1 (AFM1) biomarkers and data generated by the Sanitation Hygiene Infant Nutrition Efficacy (SHINE) trial for rural Zimbabwean women in early pregnancy. Sanitation Hygiene Infant Nutrition Efficacy is a large, cluster-randomized community-based trial in Zimbabwe designed to investigate the independent and combined effects of nutrition and hygiene interventions on early child growth. Methods and results: Urine samples collected from 1580 pregnant women in rural Zimbabwe at median gestational age of 13.9 wk were measured for AFM1. AFM1 was detected in 30% of samples (median of exposed, 162 pg AFM1/mg creatinine; range 30–6046 pg AFM1/mg). In multivariable ordinal logistic models, geographical location (p<0.001), seasonality (p < 0.001) and dietary practices (p = 0.011) were significant predictors of urinary AFM1. Conclusion: This is the largest AF biomarker survey conducted in Zimbabwe, and demonstrated frequent exposure in pregnant women with clear temporal and spatial variability in AF biomarker levels.

AB - Scope: Aflatoxins (AFs) are toxic secondary metabolites of Aspergillus species that contaminate staple foods such as maize and groundnuts. AF exposure during pregnancy has been associated with adverse birth outcomes in limited-scale surveys in sub-Saharan Africa. The objective of this study was to describe the determinants of AF exposure, using urinary aflatoxin M1 (AFM1) biomarkers and data generated by the Sanitation Hygiene Infant Nutrition Efficacy (SHINE) trial for rural Zimbabwean women in early pregnancy. Sanitation Hygiene Infant Nutrition Efficacy is a large, cluster-randomized community-based trial in Zimbabwe designed to investigate the independent and combined effects of nutrition and hygiene interventions on early child growth. Methods and results: Urine samples collected from 1580 pregnant women in rural Zimbabwe at median gestational age of 13.9 wk were measured for AFM1. AFM1 was detected in 30% of samples (median of exposed, 162 pg AFM1/mg creatinine; range 30–6046 pg AFM1/mg). In multivariable ordinal logistic models, geographical location (p<0.001), seasonality (p < 0.001) and dietary practices (p = 0.011) were significant predictors of urinary AFM1. Conclusion: This is the largest AF biomarker survey conducted in Zimbabwe, and demonstrated frequent exposure in pregnant women with clear temporal and spatial variability in AF biomarker levels.

KW - Aflatoxin

KW - Dietary diversity

KW - Pregnancy

KW - Spatial variation

KW - Temporal variation

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JO - Molecular Nutrition and Food Research

JF - Molecular Nutrition and Food Research

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ER -

Determinants of recent aflatoxin exposure among pregnant women in rural Zimbabwe

Abstract

Keywords

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