TY - JOUR
T1 - Determinants of lens vault and association with narrow angles in patients from Singapore
AU - Tan, Gavin S.
AU - He, Mingguang
AU - Zhao, Wanting
AU - Sakata, Lisandro M.
AU - Li, Jialiang
AU - Nongpiur, Monisha E.
AU - Lavanya, Raghavan
AU - Friedman, David S.
AU - Aung, Tin
N1 - Funding Information:
All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Publication of this article was supported in part by grants from Singhealth , Singapore; the National Medical Research Council , Singapore; and the National Research Foundation , Singapore. Dr Aung has received research funding, travel support, and honoraria from Carl Zeiss Meditec. Dr Friedman has received an instrument loan from Carl Zeiss Meditec. Involved in design of the study (D.F., T.A.); conduct of the study (L.S., R.L., T.A.), statistical analysis (G.T., W.Z., J.L., M.H.); and manuscript preparation (G.A., M.H., W.Z., J.L., M.N., R.L., D.F., T.A.). L.S. was a Glaucoma Fellow at the Singapore Eye Research Institute when the study was being conducted and performed all the AS-OCT measurements. D.F. helped plan the study and was a co-investigator in the grant. He was also involved in the data analysis and manuscript preparation. M.H. developed the software that was used for the AS-OCT measurements and was involved in the analysis of the results. Singapore Eye Research Institute and SingHealth Institutional Review Board Ethics Committee approval was obtained to conduct a prospective cross-sectional study of patients seen at a government primary healthcare clinic. The study adhered to the tenets of the Declaration of Helsinski.
Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012/7
Y1 - 2012/7
N2 - • PURPOSE: To describe the distribution and determinants of lens vault and to investigate the association of lens vault with narrow angles. • DESIGN: Prospective cross-sectional study. • METHODS: Phakic subjects 50 years and older were evaluated at a primary healthcare clinic with gonioscopy, partial laser interferometry, and anterior segment optical coherence tomography (AS-OCT). Narrow angles were defined as posterior trabecular meshwork not visible for <2 quadrants on non-indentation gonioscopy. Lens vault was defined as the perpendicular distance between the anterior pole of the crystalline lens and the horizontal line joining the 2 scleral spurs on horizontal AS-OCT scans. Analysis of covariance, multivariate logistic regression, and area under the receiver operating characteristic curves (AUC) were performed. • RESULTS: Of the 2047 subjects recruited, 582 were excluded because of poor image quality or inability to locate scleral spurs, leaving 1465 subjects for analysis. Eyes with narrow angles had greater lens vault compared to eyes with open angles (775.6 μm vs 386.5 μm, P < .0001). Women had significantly greater lens vault than men (497.28 μm vs 438.56 μm, P < .001), and lens vault increased significantly with age (P for trend <.001). Adjusted for age and sex, significant associations with greater lens vault were shorter axial length, shallower anterior chamber depth(ACD), higher intraocular pressure, and more hyperopic spherical equivalent (all P < .001). On multivariate analysis, subjects with lens vault >667.6 μm were more likely to have narrow angles (OR 2.201, 95% CI: 1.070-4.526) compared to those with lens vault ≤462.7 μm. The AUC for lens vault (0.816) and ACD (0.822) for detecting narrow angles were similar (P = .582). • CONCLUSIONS: Lens vault was independently associated with narrow angles and may be useful in screening to detect eyes with narrow angles.
AB - • PURPOSE: To describe the distribution and determinants of lens vault and to investigate the association of lens vault with narrow angles. • DESIGN: Prospective cross-sectional study. • METHODS: Phakic subjects 50 years and older were evaluated at a primary healthcare clinic with gonioscopy, partial laser interferometry, and anterior segment optical coherence tomography (AS-OCT). Narrow angles were defined as posterior trabecular meshwork not visible for <2 quadrants on non-indentation gonioscopy. Lens vault was defined as the perpendicular distance between the anterior pole of the crystalline lens and the horizontal line joining the 2 scleral spurs on horizontal AS-OCT scans. Analysis of covariance, multivariate logistic regression, and area under the receiver operating characteristic curves (AUC) were performed. • RESULTS: Of the 2047 subjects recruited, 582 were excluded because of poor image quality or inability to locate scleral spurs, leaving 1465 subjects for analysis. Eyes with narrow angles had greater lens vault compared to eyes with open angles (775.6 μm vs 386.5 μm, P < .0001). Women had significantly greater lens vault than men (497.28 μm vs 438.56 μm, P < .001), and lens vault increased significantly with age (P for trend <.001). Adjusted for age and sex, significant associations with greater lens vault were shorter axial length, shallower anterior chamber depth(ACD), higher intraocular pressure, and more hyperopic spherical equivalent (all P < .001). On multivariate analysis, subjects with lens vault >667.6 μm were more likely to have narrow angles (OR 2.201, 95% CI: 1.070-4.526) compared to those with lens vault ≤462.7 μm. The AUC for lens vault (0.816) and ACD (0.822) for detecting narrow angles were similar (P = .582). • CONCLUSIONS: Lens vault was independently associated with narrow angles and may be useful in screening to detect eyes with narrow angles.
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U2 - 10.1016/j.ajo.2012.01.015
DO - 10.1016/j.ajo.2012.01.015
M3 - Article
C2 - 22465367
AN - SCOPUS:84862764693
SN - 0002-9394
VL - 154
SP - 39
EP - 46
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 1
ER -