TY - JOUR
T1 - Determinants of HIV-1 load in subjects with early and later HIV infections, in a general-population cohort of Rakai, Uganda
AU - Gray, Ronald H.
AU - Li, X.
AU - Wawer, Maria J.
AU - Serwadda, David
AU - Sewankambo, Nelson K.
AU - Wabwire-Mangen, Fred
AU - Lutalo, Tom
AU - Kiwanuka, Noah
AU - Kigozi, Godfrey
AU - Nalugoda, Fred
AU - Meehan, Mary P.
AU - Robb, Merlin
AU - Quinn, Thomas C.
N1 - Funding Information:
Financial support: National Institute of Allergy and Infectious Diseases (grants RO1 AI34826 and RO1 AI3426S); National Institute of Child Health and Development (grant 5P30HD06826); Fogarty Foundation (grant 5D43TW00010); National Institutes of Health; World Bank STI Project, Uganda.
PY - 2004/4/1
Y1 - 2004/4/1
N2 - Human immunodeficiency virus (HIV) type 1 RNA loads were determined for 256 subjects with early (incident) HIV infection and for 1293 subjects with later (prevalent) HIV infection, in a Ugandan cohort. Prevalent infections were classified as latent (0-1 symptoms) and midstage disease (≥ 2 symptoms), and deaths were ascribed to acquired immunodeficiency syndrome. Among subjects with incident HIV infection, HIV load did not differ by sex, but, among subjects with prevalent HIV infection, it was higher in males than in females. HIV load was highest in subjects (25-29 years old) with incident HIV infection but increased with age in subjects with prevalent HIV infection. Viremia was higher after serconversion than in latency and increased with more advanced disease. Viremia was increased with genital ulcer disease (GUD) in both subjects with incident infection and in those with prevalent infection, and with herpes simplex virus type 2 seropositivity in subjects with incident HIV infection. GUD was consistently associated with higher HIV loads in subjects with incident and those with prevalent HIV infection, suggesting that treatment of GUD might reduce HIV viremia.
AB - Human immunodeficiency virus (HIV) type 1 RNA loads were determined for 256 subjects with early (incident) HIV infection and for 1293 subjects with later (prevalent) HIV infection, in a Ugandan cohort. Prevalent infections were classified as latent (0-1 symptoms) and midstage disease (≥ 2 symptoms), and deaths were ascribed to acquired immunodeficiency syndrome. Among subjects with incident HIV infection, HIV load did not differ by sex, but, among subjects with prevalent HIV infection, it was higher in males than in females. HIV load was highest in subjects (25-29 years old) with incident HIV infection but increased with age in subjects with prevalent HIV infection. Viremia was higher after serconversion than in latency and increased with more advanced disease. Viremia was increased with genital ulcer disease (GUD) in both subjects with incident infection and in those with prevalent infection, and with herpes simplex virus type 2 seropositivity in subjects with incident HIV infection. GUD was consistently associated with higher HIV loads in subjects with incident and those with prevalent HIV infection, suggesting that treatment of GUD might reduce HIV viremia.
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U2 - 10.1086/382750
DO - 10.1086/382750
M3 - Article
C2 - 15031789
AN - SCOPUS:11144354069
SN - 0022-1899
VL - 189
SP - 1209
EP - 1215
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 7
ER -