Detection of Malignant Tumors by Nuclear Magnetic Resonance Spectroscopy of Plasma

Fritz F. Parl; Thomas M. Harris; Brian D. Ross; Peter B. Barker; Crispin G.s. Eley; Paul G. Schmidt; John D. Roberts; Mark C. Regan; Charles Cottrell; Donald M. Small; James A. Hamilton; Robert A. Campbell; Wim J. Van Blitterswijk; Carolyn E. Mountford; Eric T. Fossel; Justine M. Carr; Jan McDonagh

doi:10.1056/NEJM198705283162214

Detection of Malignant Tumors by Nuclear Magnetic Resonance Spectroscopy of Plasma

Fritz F. Parl, Thomas M. Harris, Brian D. Ross, Peter B. Barker, Crispin G.s. Eley, Paul G. Schmidt, John D. Roberts, Mark C. Regan, Charles Cottrell, Donald M. Small, James A. Hamilton, Robert A. Campbell, Wim J. Van Blitterswijk, Carolyn E. Mountford, Eric T. Fossel, Justine M. Carr, Jan McDonagh

Research output: Contribution to journal › Letter › peer-review

30 Scopus citations

Abstract

To the Editor: We were intrigued by the study of Fossel et al. (Nov. 27 issue)¹ and the claim that water-suppressed proton nuclear magnetic resonance (NMR) spectroscopy of plasma may be useful for the detection of malignant tumors. We have compared proton NMR spectroscopy with the measurement of two tumor markers of proved value in the detection and monitoring of patients with cancer — carcinoembryonic antigen and alpha-fetoprotein.² We obtained serum from 20 patients who had elevated levels of carcinoembryonic antigen or alpha-fetoprotein and were given a diagnosis of malignant tumors. A group of 20 patients without clinical evidence of.

Original language	English (US)
Pages (from-to)	1411-1415
Number of pages	5
Journal	New England Journal of Medicine
Volume	316
Issue number	22
DOIs	https://doi.org/10.1056/NEJM198705283162214
State	Published - May 28 1987
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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Parl, F. F., Harris, T. M., Ross, B. D., Barker, P. B., Eley, C. G. S., Schmidt, P. G., Roberts, J. D., Regan, M. C., Cottrell, C., Small, D. M., Hamilton, J. A., Campbell, R. A., Van Blitterswijk, W. J., Mountford, C. E., Fossel, E. T., Carr, J. M., & McDonagh, J. (1987). Detection of Malignant Tumors by Nuclear Magnetic Resonance Spectroscopy of Plasma. New England Journal of Medicine, 316(22), 1411-1415. https://doi.org/10.1056/NEJM198705283162214

Parl, FF, Harris, TM, Ross, BD, Barker, PB, Eley, CGS, Schmidt, PG, Roberts, JD, Regan, MC, Cottrell, C, Small, DM, Hamilton, JA, Campbell, RA, Van Blitterswijk, WJ, Mountford, CE, Fossel, ET, Carr, JM & McDonagh, J 1987, 'Detection of Malignant Tumors by Nuclear Magnetic Resonance Spectroscopy of Plasma', New England Journal of Medicine, vol. 316, no. 22, pp. 1411-1415. https://doi.org/10.1056/NEJM198705283162214

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title = "Detection of Malignant Tumors by Nuclear Magnetic Resonance Spectroscopy of Plasma",

abstract = "To the Editor: We were intrigued by the study of Fossel et al. (Nov. 27 issue)1 and the claim that water-suppressed proton nuclear magnetic resonance (NMR) spectroscopy of plasma may be useful for the detection of malignant tumors. We have compared proton NMR spectroscopy with the measurement of two tumor markers of proved value in the detection and monitoring of patients with cancer — carcinoembryonic antigen and alpha-fetoprotein.2 We obtained serum from 20 patients who had elevated levels of carcinoembryonic antigen or alpha-fetoprotein and were given a diagnosis of malignant tumors. A group of 20 patients without clinical evidence of.",

author = "Parl, {Fritz F.} and Harris, {Thomas M.} and Ross, {Brian D.} and Barker, {Peter B.} and Eley, {Crispin G.s.} and Schmidt, {Paul G.} and Roberts, {John D.} and Regan, {Mark C.} and Charles Cottrell and Small, {Donald M.} and Hamilton, {James A.} and Campbell, {Robert A.} and {Van Blitterswijk}, {Wim J.} and Mountford, {Carolyn E.} and Fossel, {Eric T.} and Carr, {Justine M.} and Jan McDonagh",

year = "1987",

month = may,

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doi = "10.1056/NEJM198705283162214",

language = "English (US)",

volume = "316",

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T1 - Detection of Malignant Tumors by Nuclear Magnetic Resonance Spectroscopy of Plasma

AU - Parl, Fritz F.

AU - Harris, Thomas M.

AU - Ross, Brian D.

AU - Barker, Peter B.

AU - Eley, Crispin G.s.

AU - Schmidt, Paul G.

AU - Roberts, John D.

AU - Regan, Mark C.

AU - Cottrell, Charles

AU - Small, Donald M.

AU - Hamilton, James A.

AU - Campbell, Robert A.

AU - Van Blitterswijk, Wim J.

AU - Mountford, Carolyn E.

AU - Fossel, Eric T.

AU - Carr, Justine M.

AU - McDonagh, Jan

PY - 1987/5/28

Y1 - 1987/5/28

N2 - To the Editor: We were intrigued by the study of Fossel et al. (Nov. 27 issue)1 and the claim that water-suppressed proton nuclear magnetic resonance (NMR) spectroscopy of plasma may be useful for the detection of malignant tumors. We have compared proton NMR spectroscopy with the measurement of two tumor markers of proved value in the detection and monitoring of patients with cancer — carcinoembryonic antigen and alpha-fetoprotein.2 We obtained serum from 20 patients who had elevated levels of carcinoembryonic antigen or alpha-fetoprotein and were given a diagnosis of malignant tumors. A group of 20 patients without clinical evidence of.

AB - To the Editor: We were intrigued by the study of Fossel et al. (Nov. 27 issue)1 and the claim that water-suppressed proton nuclear magnetic resonance (NMR) spectroscopy of plasma may be useful for the detection of malignant tumors. We have compared proton NMR spectroscopy with the measurement of two tumor markers of proved value in the detection and monitoring of patients with cancer — carcinoembryonic antigen and alpha-fetoprotein.2 We obtained serum from 20 patients who had elevated levels of carcinoembryonic antigen or alpha-fetoprotein and were given a diagnosis of malignant tumors. A group of 20 patients without clinical evidence of.

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Detection of Malignant Tumors by Nuclear Magnetic Resonance Spectroscopy of Plasma

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