Detection of infection with human immunedeficiency virus type 1 before seroconversion: Correlation with clinical symptoms and outcome

John P. Phair; Joseph B. Margolick; Lisa P. Jacobson; Jack Phillips; Charles Rinaldo; Richard Kaslow; Clara Chu; Janis V. Giorgi; Denis Henrard

doi:10.1086/514000

Detection of infection with human immunedeficiency virus type 1 before seroconversion: Correlation with clinical symptoms and outcome

John P. Phair, Joseph B. Margolick, Lisa P. Jacobson, Jack Phillips, Charles Rinaldo, Richard Kaslow, Clara Chu, Janis V. Giorgi, Denis Henrard

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Early (pre-seroconversion) infection with human immunodeficiency virus type 1 (HIV-1) was identified in 50 of 267 participants in the Multicenter AIDS Cohort Study. These 50 men had a positive EIA result, which detected IgM antibody (n = 35), p24 antigen, or serum HIV RNA (n = 15) at their last 'seronegative' visit. At that visit, the mean CD4 lymphocyte number (890/mm³ vs. 1038/mm³) was significantly lower than in men who subsequently seroconverted but had no evidence of early infection. The decline in CD4 cells was slower and the duration of AIDS-free time longer in the 19 men who were symptomatic in comparison to the 31 asymptomatic men with early infection, but differences were not significant.

Original language	English (US)
Pages (from-to)	959-962
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	175
Issue number	4
DOIs	https://doi.org/10.1086/514000
State	Published - 1997

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

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10.1086/514000

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title = "Detection of infection with human immunedeficiency virus type 1 before seroconversion: Correlation with clinical symptoms and outcome",

abstract = "Early (pre-seroconversion) infection with human immunodeficiency virus type 1 (HIV-1) was identified in 50 of 267 participants in the Multicenter AIDS Cohort Study. These 50 men had a positive EIA result, which detected IgM antibody (n = 35), p24 antigen, or serum HIV RNA (n = 15) at their last 'seronegative' visit. At that visit, the mean CD4 lymphocyte number (890/mm3 vs. 1038/mm3) was significantly lower than in men who subsequently seroconverted but had no evidence of early infection. The decline in CD4 cells was slower and the duration of AIDS-free time longer in the 19 men who were symptomatic in comparison to the 31 asymptomatic men with early infection, but differences were not significant.",

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T1 - Detection of infection with human immunedeficiency virus type 1 before seroconversion

T2 - Correlation with clinical symptoms and outcome

AU - Phair, John P.

AU - Margolick, Joseph B.

AU - Jacobson, Lisa P.

AU - Phillips, Jack

AU - Rinaldo, Charles

AU - Kaslow, Richard

AU - Chu, Clara

AU - Giorgi, Janis V.

AU - Henrard, Denis

PY - 1997

Y1 - 1997

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AB - Early (pre-seroconversion) infection with human immunodeficiency virus type 1 (HIV-1) was identified in 50 of 267 participants in the Multicenter AIDS Cohort Study. These 50 men had a positive EIA result, which detected IgM antibody (n = 35), p24 antigen, or serum HIV RNA (n = 15) at their last 'seronegative' visit. At that visit, the mean CD4 lymphocyte number (890/mm3 vs. 1038/mm3) was significantly lower than in men who subsequently seroconverted but had no evidence of early infection. The decline in CD4 cells was slower and the duration of AIDS-free time longer in the 19 men who were symptomatic in comparison to the 31 asymptomatic men with early infection, but differences were not significant.

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Detection of infection with human immunedeficiency virus type 1 before seroconversion: Correlation with clinical symptoms and outcome

Abstract

ASJC Scopus subject areas

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