Detection of Human Papillomavirus in Clinical Samples

William H. Westra

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


The confirmation of human papillomavirus (HPV) as a causative agent for a subset of squamous cell carcinomas of the head and neck has resulted in a growing expectation for HPV testing in head and neck cancers. An increasing understanding of HPV-related tumorigenesis has informed this evaluation process in a manner that is moving wide scale, indiscriminant, and nonstandardized testing toward a more directed, clinically relevant, and standardized approach. This review addresses the current state of HPV detection and focuses on the importance, appropriate time, and need for HPV testing.

Original languageEnglish (US)
Pages (from-to)765-777
Number of pages13
JournalOtolaryngologic Clinics of North America
Issue number4
StatePublished - Aug 2012


  • Hybrid capture 2
  • In situ hybridization
  • Oropharyngeal carcinoma
  • P16 immunohistochemistry
  • Squamous cell carcinoma of the head and neck

ASJC Scopus subject areas

  • Otorhinolaryngology


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