Detection of Five Components Having Antibody Activity in Rat Antisera

Jay Banovitz; Kimishige Ishizaka

doi:10.3181/00379727-125-32018

Detection of Five Components Having Antibody Activity in Rat Antisera

Jay Banovitz
, Kimishige Ishizaka

School of Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

By radioimmunoelectrophoresis, antibodies associated with γ₁, γ₂ and γM globulins and 2 unidentified components, U₁ and U₂, were detected in rat antisera to BSA and BGG. When rats were immunized with these antigens adsorbed to bentonite or included in complete Freund's adjuvant, the sequence of the immune response in rats involves first the formation of γ₁ antibody followed upon further immunization by γ₂ antibody. Generally, γM and the unknown components, U₁ and U₂, only appeared in hyperimmune sera.

Original language	English (US)
Pages (from-to)	78-82
Number of pages	5
Journal	Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)
Volume	125
Issue number	1
DOIs	https://doi.org/10.3181/00379727-125-32018
State	Published - May 1967

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

Access to Document

10.3181/00379727-125-32018

Cite this

@article{d229898d47b54c0f904eff5a3ec09fc4,

title = "Detection of Five Components Having Antibody Activity in Rat Antisera",

abstract = "By radioimmunoelectrophoresis, antibodies associated with γ1, γ2 and γM globulins and 2 unidentified components, U1 and U2, were detected in rat antisera to BSA and BGG. When rats were immunized with these antigens adsorbed to bentonite or included in complete Freund's adjuvant, the sequence of the immune response in rats involves first the formation of γ1 antibody followed upon further immunization by γ2 antibody. Generally, γM and the unknown components, U1 and U2, only appeared in hyperimmune sera.",

author = "Jay Banovitz and Kimishige Ishizaka",

note = "Funding Information: This work was supported by USPHS Research Grants AI-05840, AI-07613 and AI-04985. ",

year = "1967",

month = may,

doi = "10.3181/00379727-125-32018",

language = "English (US)",

volume = "125",

pages = "78--82",

journal = "Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)",

issn = "0037-9727",

publisher = "Society for Experimental Biology and Medicine",

number = "1",

}

TY - JOUR

T1 - Detection of Five Components Having Antibody Activity in Rat Antisera

AU - Banovitz, Jay

AU - Ishizaka, Kimishige

N1 - Funding Information: This work was supported by USPHS Research Grants AI-05840, AI-07613 and AI-04985.

PY - 1967/5

Y1 - 1967/5

N2 - By radioimmunoelectrophoresis, antibodies associated with γ1, γ2 and γM globulins and 2 unidentified components, U1 and U2, were detected in rat antisera to BSA and BGG. When rats were immunized with these antigens adsorbed to bentonite or included in complete Freund's adjuvant, the sequence of the immune response in rats involves first the formation of γ1 antibody followed upon further immunization by γ2 antibody. Generally, γM and the unknown components, U1 and U2, only appeared in hyperimmune sera.

AB - By radioimmunoelectrophoresis, antibodies associated with γ1, γ2 and γM globulins and 2 unidentified components, U1 and U2, were detected in rat antisera to BSA and BGG. When rats were immunized with these antigens adsorbed to bentonite or included in complete Freund's adjuvant, the sequence of the immune response in rats involves first the formation of γ1 antibody followed upon further immunization by γ2 antibody. Generally, γM and the unknown components, U1 and U2, only appeared in hyperimmune sera.

UR - https://www.scopus.com/pages/publications/0014082220

UR - https://www.scopus.com/pages/publications/0014082220#tab=citedBy

U2 - 10.3181/00379727-125-32018

DO - 10.3181/00379727-125-32018

M3 - Article

C2 - 4165488

AN - SCOPUS:0014082220

SN - 0037-9727

VL - 125

SP - 78

EP - 82

JO - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)

JF - Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N. Y.)

IS - 1

ER -

Detection of Five Components Having Antibody Activity in Rat Antisera

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this