Detection of familial adenomatous polyposis with orthogonal polarized spectroscopy of the oral mucosa vasculature

Ali Basiri; Daniel L. Edelstein; Jenna Graham; Afshin Nabili; Francis M. Giardiello; Jessica C. Ramella-Roman

doi:10.1002/jbio.201100057

Detection of familial adenomatous polyposis with orthogonal polarized spectroscopy of the oral mucosa vasculature

Ali Basiri, Daniel L. Edelstein, Jenna Graham, Afshin Nabili, Francis M. Giardiello, Jessica C. Ramella-Roman

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Familial Adenomatous Polyposis (FAP) is an autosomal dominant disease characterized by the development of multiple colonic polyps at younger age with a near 100% lifetime risk of colorectal cancer. The determination of FAP is made after extensive clinical evaluation and genetic testing of at risk individuals. We investigated a novel spectro-polarimetric imaging system capable of capturing high-resolution images of the oral mucosa at different wavelengths in an attempt to distinguish patients with FAP from controls. Results of a clinical trial show that the system is capable of separating FAP positive individuals from controls by measuring the individuals' oral vascular density and complexity.

Original language	English (US)
Pages (from-to)	707-714
Number of pages	8
Journal	Journal of biophotonics
Volume	4
Issue number	10
DOIs	https://doi.org/10.1002/jbio.201100057
State	Published - Oct 2011
Externally published	Yes

Keywords

Colon cancer
Oral mucosa
Reflectance
Vessel density

ASJC Scopus subject areas

General Chemistry
General Materials Science
General Biochemistry, Genetics and Molecular Biology
General Engineering
General Physics and Astronomy

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10.1002/jbio.201100057

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title = "Detection of familial adenomatous polyposis with orthogonal polarized spectroscopy of the oral mucosa vasculature",

abstract = "Familial Adenomatous Polyposis (FAP) is an autosomal dominant disease characterized by the development of multiple colonic polyps at younger age with a near 100% lifetime risk of colorectal cancer. The determination of FAP is made after extensive clinical evaluation and genetic testing of at risk individuals. We investigated a novel spectro-polarimetric imaging system capable of capturing high-resolution images of the oral mucosa at different wavelengths in an attempt to distinguish patients with FAP from controls. Results of a clinical trial show that the system is capable of separating FAP positive individuals from controls by measuring the individuals' oral vascular density and complexity.",

keywords = "Colon cancer, Oral mucosa, Reflectance, Vessel density",

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year = "2011",

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T1 - Detection of familial adenomatous polyposis with orthogonal polarized spectroscopy of the oral mucosa vasculature

AU - Basiri, Ali

AU - Edelstein, Daniel L.

AU - Graham, Jenna

AU - Nabili, Afshin

AU - Giardiello, Francis M.

AU - Ramella-Roman, Jessica C.

PY - 2011/10

Y1 - 2011/10

N2 - Familial Adenomatous Polyposis (FAP) is an autosomal dominant disease characterized by the development of multiple colonic polyps at younger age with a near 100% lifetime risk of colorectal cancer. The determination of FAP is made after extensive clinical evaluation and genetic testing of at risk individuals. We investigated a novel spectro-polarimetric imaging system capable of capturing high-resolution images of the oral mucosa at different wavelengths in an attempt to distinguish patients with FAP from controls. Results of a clinical trial show that the system is capable of separating FAP positive individuals from controls by measuring the individuals' oral vascular density and complexity.

AB - Familial Adenomatous Polyposis (FAP) is an autosomal dominant disease characterized by the development of multiple colonic polyps at younger age with a near 100% lifetime risk of colorectal cancer. The determination of FAP is made after extensive clinical evaluation and genetic testing of at risk individuals. We investigated a novel spectro-polarimetric imaging system capable of capturing high-resolution images of the oral mucosa at different wavelengths in an attempt to distinguish patients with FAP from controls. Results of a clinical trial show that the system is capable of separating FAP positive individuals from controls by measuring the individuals' oral vascular density and complexity.

KW - Colon cancer

KW - Oral mucosa

KW - Reflectance

KW - Vessel density

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Detection of familial adenomatous polyposis with orthogonal polarized spectroscopy of the oral mucosa vasculature

Abstract

Keywords

ASJC Scopus subject areas

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