Detection of Epstein Barr virus DNA in American Burkitt's lymphoma

J. L. Ziegler, M. Andersson, G. Klein, W. Henle

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53 Scopus citations


Twenty American patients with Burkitt's lymphoma (BL) were studied serologically and biochemically to detect an association with Epstein Barr virus (EBV). A wide range of antibody reactivities was encountered. Five patients had serological profiles similar to those of African patients with BL: 1 and possibly 2 of these patients harbored EBV-DNA in their tumors. Fifteen patients had low or absent antibody to EBV: tumors from 10 of these patients lacked evidence of EBV-DNA. An unexplained association between elevated antibody (≥1:80) to EBV virus capsid antigen (VCA) and a favorable prognosis was noted in this series; this prognostic observation requires further substantiation. Thus, it appears that EBV associated BL is inversely proportional to tumor endemicity. An etiological role for EBV in BL remains speculative.

Original languageEnglish (US)
Pages (from-to)701-706
Number of pages6
JournalInternational Journal of Cancer
Issue number6
StatePublished - 1976
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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