Detection and Characterization of Musculoskeletal Cancer Using Whole-Body Magnetic Resonance Imaging

Amanda Isaac, Frederic Lecouvet, Danoob Dalili, Laura Fayad, Vasiliki Pasoglou, Olympia Papakonstantinou, Shivani Ahlawat, Christina Messiou, Marc André Weber, Anwar R. Padhani

Research output: Contribution to journalArticlepeer-review


Whole-body magnetic resonance imaging (WB-MRI) is gradually being integrated into clinical pathways for the detection, characterization, and staging of malignant tumors including those arising in the musculoskeletal (MSK) system. Although further developments and research are needed, it is now recognized that WB-MRI enables reliable, sensitive, and specific detection and quantification of disease burden, with clinical applications for a variety of disease types and a particular application for skeletal involvement. Advances in imaging techniques now allow the reliable incorporation of WB-MRI into clinical pathways, and guidelines recommending its use are emerging. This review assesses the benefits, clinical applications, limitations, and future capabilities of WB-MRI in the context of other next-generation imaging modalities, as a qualitative and quantitative tool for the detection and characterization of skeletal and soft tissue MSK malignancies.

Original languageEnglish (US)
Pages (from-to)726-749
Number of pages24
JournalSeminars in Musculoskeletal Radiology
Issue number6
StatePublished - Dec 1 2020


  • bone metastasis
  • myeloma
  • next-generation imaging
  • precision oncology
  • whole-body MRI

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Radiology Nuclear Medicine and imaging


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