Detectable tenofovir levels in breast-feeding infants of mothers exposed to topical tenofovir

Lisa M. Noguchi; Elizabeth T. Montgomery; Joseph R. Biggio; Craig W. Hendrix; Debra L. Bogen; Sharon L. Hillier; James Y. Dai; Jeanna M. Piper; Mark A. Marzinke; Charlene S. Dezzutti; S. Karen Isaacs; Jill L. Schwartz; D. Heather Watts; Richard H. Beigi

doi:10.1128/AAC.00645-16

Detectable tenofovir levels in breast-feeding infants of mothers exposed to topical tenofovir

Lisa M. Noguchi, Elizabeth T. Montgomery, Joseph R. Biggio, Craig W. Hendrix, Debra L. Bogen, Sharon L. Hillier, James Y. Dai, Jeanna M. Piper, Mark A. Marzinke, Charlene S. Dezzutti, S. Karen Isaacs, Jill L. Schwartz, D. Heather Watts, Richard H. Beigi

School of Medicine

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Lactation studies are necessary evaluations of medications for reproductive-age women. We evaluated pharmacokinetics (PK), pharmacodynamics, safety, and adherence profiles associated with 7 days of 1% tenofovir (TFV) vaginal gel use during lactation. Tenofovir levels (maternal/infant serum, milk) and anti-HIV activity (milk), adverse events (AEs), and adherence were measured for 17 HIV-1-seronegative breast-feeding mother-infant pairs. Tenofovir use was well-tolerated and detected at low levels in maternal serum, milk, and infant serum but demonstrated no anti-HIV activity in milk.

Original language	English (US)
Pages (from-to)	5616-5619
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	60
Issue number	9
DOIs	https://doi.org/10.1128/AAC.00645-16
State	Published - Sep 1 2016

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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Noguchi, L. M., Montgomery, E. T., Biggio, J. R., Hendrix, C. W., Bogen, D. L., Hillier, S. L., Dai, J. Y., Piper, J. M., Marzinke, M. A., Dezzutti, C. S., Isaacs, S. K., Schwartz, J. L., Watts, D. H., & Beigi, R. H. (2016). Detectable tenofovir levels in breast-feeding infants of mothers exposed to topical tenofovir. Antimicrobial agents and chemotherapy, 60(9), 5616-5619. https://doi.org/10.1128/AAC.00645-16

Noguchi, LM, Montgomery, ET, Biggio, JR, Hendrix, CW, Bogen, DL, Hillier, SL, Dai, JY, Piper, JM, Marzinke, MA, Dezzutti, CS, Isaacs, SK, Schwartz, JL, Watts, DH & Beigi, RH 2016, 'Detectable tenofovir levels in breast-feeding infants of mothers exposed to topical tenofovir', Antimicrobial agents and chemotherapy, vol. 60, no. 9, pp. 5616-5619. https://doi.org/10.1128/AAC.00645-16

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abstract = "Lactation studies are necessary evaluations of medications for reproductive-age women. We evaluated pharmacokinetics (PK), pharmacodynamics, safety, and adherence profiles associated with 7 days of 1% tenofovir (TFV) vaginal gel use during lactation. Tenofovir levels (maternal/infant serum, milk) and anti-HIV activity (milk), adverse events (AEs), and adherence were measured for 17 HIV-1-seronegative breast-feeding mother-infant pairs. Tenofovir use was well-tolerated and detected at low levels in maternal serum, milk, and infant serum but demonstrated no anti-HIV activity in milk.",

author = "Noguchi, {Lisa M.} and Montgomery, {Elizabeth T.} and Biggio, {Joseph R.} and Hendrix, {Craig W.} and Bogen, {Debra L.} and Hillier, {Sharon L.} and Dai, {James Y.} and Piper, {Jeanna M.} and Marzinke, {Mark A.} and Dezzutti, {Charlene S.} and Isaacs, {S. Karen} and Schwartz, {Jill L.} and Watts, {D. Heather} and Beigi, {Richard H.}",

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AU - Bogen, Debra L.

AU - Hillier, Sharon L.

AU - Dai, James Y.

AU - Piper, Jeanna M.

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AU - Dezzutti, Charlene S.

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Detectable tenofovir levels in breast-feeding infants of mothers exposed to topical tenofovir

Abstract

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