Designing dendritic frameworks using versatile building blocks suitable for CuI-catalyzed alkyne azide 'click' chemistry

Rami Hourani; Anjali Sharma; Ashok Kakkar

doi:10.1016/j.tetlet.2010.05.061

Designing dendritic frameworks using versatile building blocks suitable for Cu^I-catalyzed alkyne azide 'click' chemistry

Rami Hourani, Anjali Sharma, Ashok Kakkar

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Synthesis of molecular building blocks that incorporate azide and alkyne-terminated functionalities suitable for Cu^I-catalyzed cycloaddition between alkynes and azides is reported. Their utility in constructing dendritic frameworks with 4, 6, or 12 peripheral acetylene groups using either the convergent or divergent methodology, and their functionalization with desirable end groups are demonstrated.

Original language	English (US)
Pages (from-to)	3792-3795
Number of pages	4
Journal	Tetrahedron Letters
Volume	51
Issue number	29
DOIs	https://doi.org/10.1016/j.tetlet.2010.05.061
State	Published - Jul 21 2010
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2010.05.061

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abstract = "Synthesis of molecular building blocks that incorporate azide and alkyne-terminated functionalities suitable for CuI-catalyzed cycloaddition between alkynes and azides is reported. Their utility in constructing dendritic frameworks with 4, 6, or 12 peripheral acetylene groups using either the convergent or divergent methodology, and their functionalization with desirable end groups are demonstrated.",

author = "Rami Hourani and Anjali Sharma and Ashok Kakkar",

note = "Funding Information: We would like to thank NSERC (Canada) and Center for Self-Assembled Chemical Structures (FQRNT, Qc Canada) for financial assistance, and for a post-graduate fellowship to R.H. ",

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AU - Hourani, Rami

AU - Sharma, Anjali

AU - Kakkar, Ashok

N1 - Funding Information: We would like to thank NSERC (Canada) and Center for Self-Assembled Chemical Structures (FQRNT, Qc Canada) for financial assistance, and for a post-graduate fellowship to R.H.

PY - 2010/7/21

Y1 - 2010/7/21

N2 - Synthesis of molecular building blocks that incorporate azide and alkyne-terminated functionalities suitable for CuI-catalyzed cycloaddition between alkynes and azides is reported. Their utility in constructing dendritic frameworks with 4, 6, or 12 peripheral acetylene groups using either the convergent or divergent methodology, and their functionalization with desirable end groups are demonstrated.

AB - Synthesis of molecular building blocks that incorporate azide and alkyne-terminated functionalities suitable for CuI-catalyzed cycloaddition between alkynes and azides is reported. Their utility in constructing dendritic frameworks with 4, 6, or 12 peripheral acetylene groups using either the convergent or divergent methodology, and their functionalization with desirable end groups are demonstrated.

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Designing dendritic frameworks using versatile building blocks suitable for Cu^I-catalyzed alkyne azide 'click' chemistry

Abstract

ASJC Scopus subject areas

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