Design, synthesis and evaluation of new RDP inhibitors

Hallur Gurulingappa; Phillip Buckhaults; Srinivas K. Kumar; Kenneth W. Kinzler; Bert Vogelstein; Saeed R. Khan

doi:10.1016/S0040-4039(03)00082-0

Design, synthesis and evaluation of new RDP inhibitors

Hallur Gurulingappa, Phillip Buckhaults, Srinivas K. Kumar, Kenneth W. Kinzler, Bert Vogelstein, Saeed R. Khan

School of Medicine

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Aminophosphinic acid derivatives were synthesized as potential inhibitors of renal dipeptidase, an enzyme overexpressed in benign and malignant colon tumors. Several compounds showed potent enzyme-inhibitory activity.

Original language	English (US)
Pages (from-to)	1871-1873
Number of pages	3
Journal	Tetrahedron Letters
Volume	44
Issue number	9
DOIs	https://doi.org/10.1016/S0040-4039(03)00082-0
State	Published - Feb 24 2003

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(03)00082-0

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title = "Design, synthesis and evaluation of new RDP inhibitors",

abstract = "Aminophosphinic acid derivatives were synthesized as potential inhibitors of renal dipeptidase, an enzyme overexpressed in benign and malignant colon tumors. Several compounds showed potent enzyme-inhibitory activity.",

author = "Hallur Gurulingappa and Phillip Buckhaults and Kumar, {Srinivas K.} and Kinzler, {Kenneth W.} and Bert Vogelstein and Khan, {Saeed R.}",

note = "Funding Information: We are grateful for the support provided by the National Institute of Health. We would like to thank the Biophysical Chemistry Department for NMR studies.",

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T1 - Design, synthesis and evaluation of new RDP inhibitors

AU - Gurulingappa, Hallur

AU - Buckhaults, Phillip

AU - Kumar, Srinivas K.

AU - Kinzler, Kenneth W.

AU - Vogelstein, Bert

AU - Khan, Saeed R.

N1 - Funding Information: We are grateful for the support provided by the National Institute of Health. We would like to thank the Biophysical Chemistry Department for NMR studies.

PY - 2003/2/24

Y1 - 2003/2/24

N2 - Aminophosphinic acid derivatives were synthesized as potential inhibitors of renal dipeptidase, an enzyme overexpressed in benign and malignant colon tumors. Several compounds showed potent enzyme-inhibitory activity.

AB - Aminophosphinic acid derivatives were synthesized as potential inhibitors of renal dipeptidase, an enzyme overexpressed in benign and malignant colon tumors. Several compounds showed potent enzyme-inhibitory activity.

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U2 - 10.1016/S0040-4039(03)00082-0

DO - 10.1016/S0040-4039(03)00082-0

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VL - 44

SP - 1871

EP - 1873

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 9

ER -

Design, synthesis and evaluation of new RDP inhibitors

Abstract

ASJC Scopus subject areas

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