Design of minimally invasive optical imaging probes to track vascular gene expression: A monte carlo simulation analysis

Ananda Kumar; Hunter H. Chen; Erin Long; Xiaoming Yang

doi:10.1109/ISBI.2002.1029249

Design of minimally invasive optical imaging probes to track vascular gene expression: A monte carlo simulation analysis

Ananda Kumar, Hunter H. Chen, Erin Long, Xiaoming Yang

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

2 Scopus citations

Abstract

A Monte Carlo simulation analysis of optical probe design for minimally invasive tracking of gene expression in the vasculature was performed. The simulations based on efficient light delivery for excitation of green fluorescent protein (GFP) marker revealed the possibility of using percutaneous probes and intravascular probes to detect gene expression in the vessel walls. A percutaneous probe of 5 mm diameter and an intravascular probe of 2mm diameter produced identical fluence distribution in the media-intima interface of a diseased aorta for optimal excitation of GFP. But there was a seven-fold increase in the fluence rate in the normal aorta by the intravascular probe.

Original language	English (US)
Title of host publication	2002 IEEE International Symposium on Biomedical Imaging, ISBI 2002 - Proceedings
Publisher	IEEE Computer Society
Pages	285-288
Number of pages	4
ISBN (Electronic)	078037584X
DOIs	https://doi.org/10.1109/ISBI.2002.1029249
State	Published - Jan 1 2002
Event	IEEE International Symposium on Biomedical Imaging, ISBI 2002 - Washington, United States Duration: Jul 7 2002 → Jul 10 2002

Publication series

Name	Proceedings - International Symposium on Biomedical Imaging
Volume	2002-January
ISSN (Print)	1945-7928
ISSN (Electronic)	1945-8452

Other

Other	IEEE International Symposium on Biomedical Imaging, ISBI 2002
Country/Territory	United States
City	Washington
Period	7/7/02 → 7/10/02

ASJC Scopus subject areas

Biomedical Engineering
Radiology Nuclear Medicine and imaging

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10.1109/ISBI.2002.1029249

Cite this

Kumar, A., Chen, H. H., Long, E., & Yang, X. (2002). Design of minimally invasive optical imaging probes to track vascular gene expression: A monte carlo simulation analysis. In 2002 IEEE International Symposium on Biomedical Imaging, ISBI 2002 - Proceedings (pp. 285-288). [1029249] (Proceedings - International Symposium on Biomedical Imaging; Vol. 2002-January). IEEE Computer Society. https://doi.org/10.1109/ISBI.2002.1029249

Design of minimally invasive optical imaging probes to track vascular gene expression: A monte carlo simulation analysis. / Kumar, Ananda; Chen, Hunter H.; Long, Erin et al.
2002 IEEE International Symposium on Biomedical Imaging, ISBI 2002 - Proceedings. IEEE Computer Society, 2002. p. 285-288 1029249 (Proceedings - International Symposium on Biomedical Imaging; Vol. 2002-January).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Kumar, A, Chen, HH, Long, E & Yang, X 2002, Design of minimally invasive optical imaging probes to track vascular gene expression: A monte carlo simulation analysis. in 2002 IEEE International Symposium on Biomedical Imaging, ISBI 2002 - Proceedings., 1029249, Proceedings - International Symposium on Biomedical Imaging, vol. 2002-January, IEEE Computer Society, pp. 285-288, IEEE International Symposium on Biomedical Imaging, ISBI 2002, Washington, United States, 7/7/02. https://doi.org/10.1109/ISBI.2002.1029249

Kumar A, Chen HH, Long E, Yang X. Design of minimally invasive optical imaging probes to track vascular gene expression: A monte carlo simulation analysis. In 2002 IEEE International Symposium on Biomedical Imaging, ISBI 2002 - Proceedings. IEEE Computer Society. 2002. p. 285-288. 1029249. (Proceedings - International Symposium on Biomedical Imaging). doi: 10.1109/ISBI.2002.1029249

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Design of minimally invasive optical imaging probes to track vascular gene expression: A monte carlo simulation analysis

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