TY - GEN
T1 - Design of a Custom Flexible Ultrasound Transducer as an Implantable Cranial Sensor for Long-Term Post-Operative Monitoring of Brain Tumor Regrowth
AU - Leadingham, Kelley M.Kempski
AU - Abramson, Haley G.
AU - Perdomo-Pantoja, Alexander
AU - Thombre, Rasika
AU - Liu, Joshua
AU - Norman, Madison
AU - Chavez, Francisco
AU - Morrison, Kyle
AU - Suk, Ian
AU - Gordon, Chad R
AU - Armand, Mehran
AU - Manbachi, Amir
N1 - Funding Information:
Funding was provided by Defense Advanced Research Projects Agency (DARPA) Award Contract N660012024075, Johns Hopkins University Cohen Translational Engineering Fund, and National Science Foundation (NSF) Graduate Research Fellowship DGE1746891. AM acknowledges funding from Johns Hopkins Institute for Clinical and Translational Research’s Clinical Research Scholars Program (KL2), administered by the National Center for Advancing Translational Sciences (NCATS), National Institute of Health (NIH KL2 TR003099).
Publisher Copyright:
© 2022 IEEE.
PY - 2022
Y1 - 2022
N2 - Glioblastoma is a highly invasive, malignant brain tumor that affects over 13,000 patients in the United States each year, with a high rate of recurrence following resection. One possible solution to allow for long-term brain monitoring involves integrating wearable or implantable ultrasound devices with cranial implants. The objective of this study was to design, develop, and characterize and test a novel ultrasound probe that could be used in conjunction with a sonoluscent cranial implant to provide long-term brain monitoring following neurosurgery. A cranioplasty was performed on a human cadaver head and a cranial implant was placed over an ex vivo porcine brain, and ultrasound images of the brains with implanted tumors were captured using a custom, flexible ultrasound transducer. This proof of concept study lays the promising groundwork for the production of a wireless transducer housed inside of a cranial implant to provide long-term brain monitoring.
AB - Glioblastoma is a highly invasive, malignant brain tumor that affects over 13,000 patients in the United States each year, with a high rate of recurrence following resection. One possible solution to allow for long-term brain monitoring involves integrating wearable or implantable ultrasound devices with cranial implants. The objective of this study was to design, develop, and characterize and test a novel ultrasound probe that could be used in conjunction with a sonoluscent cranial implant to provide long-term brain monitoring following neurosurgery. A cranioplasty was performed on a human cadaver head and a cranial implant was placed over an ex vivo porcine brain, and ultrasound images of the brains with implanted tumors were captured using a custom, flexible ultrasound transducer. This proof of concept study lays the promising groundwork for the production of a wireless transducer housed inside of a cranial implant to provide long-term brain monitoring.
KW - glioblastoma
KW - implantable sensor
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=85143804485&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85143804485&partnerID=8YFLogxK
U2 - 10.1109/IUS54386.2022.9958345
DO - 10.1109/IUS54386.2022.9958345
M3 - Conference contribution
AN - SCOPUS:85143804485
T3 - IEEE International Ultrasonics Symposium, IUS
BT - IUS 2022 - IEEE International Ultrasonics Symposium
PB - IEEE Computer Society
T2 - 2022 IEEE International Ultrasonics Symposium, IUS 2022
Y2 - 10 October 2022 through 13 October 2022
ER -