Descripción de la presencia de anticuerpos antianexina v, cardiolipina y β2-glicoproteína i en mujeres con pérdidas gestacionales recurrentes en la ciudad de medellín, Colombia

Translated title of the contribution: Describing the presence of anti-annexin v antibodies, cardiolipin and β2-glycoprotein 1 in females suffering recurrent pregnancy loss in medellin, Colombia

María Victoria Mejía-Mejía, ángela María Segura-Cardona, María Camila Velásquez-Escobar, María Camila Arango-White, Jazmín Abad-Restrepo, Martín Orrego-Vélez, Santiago álvarez-Arango, Carlos Ignacio Uribe-Pardo

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Describing anti-annexin V antibody frequency in a series of females suffering recurrent abortion in Medellin. Materials and methods: A series of cases was compiled, consisting of healthy females attending gynecological consultation who had a background of recurrent pregnancy loss (RPL), characterized by two or more abortions during the first three months of pregnancy. The females were attending a second- and third-level complexity healthcareproviding institution and/or private consultation with some gynecologists in Medellin who agreed to participate in the study. Females diagnosed with secondary antiphospholipid syndrome were excluded. Socio-demographic characteristics, obstetric and medical background emphasizing hypertension and thrombosis were evaluated, as were anti-cardiolipin antibodies, lupus anticoagulant, number of anti-β2-GPI antibodies and number of anti-annexin V antibodies. Such information was tabulated on a Microsoft Excel sheet and processed using Stata 10.0 statistical software; descriptive statistics were used for statistical analysis. Results: 65 females were surveyed, their ages ranging from 18 to 46 years. Half the patients reported 2 abortions before the tenth week and the other half following such time. Anti-cardiolipin antibody results revealed that 4.6% (3) of the patients proved positive for IgM antibodies and 3.1% (2) positive for IgG antibodies. 3.1% (2) of the females had IgG and IgM anti-β2-GPI antibodies. 4.6% (3) of the patients were positive for anti-annexin IgG antibodies and 12.3% (8) had an indeterminate result. Conclusions: Anti-annexin antibodies were detected in the patients surveyed in this study, although a subgroup of females had an indeterminate result. This led to advancing a hypothesis that annexin V could be an important and independent factor for cardiolipin and β2-GPI antibodies in recurrent pregnancy loss.

Translated title of the contributionDescribing the presence of anti-annexin v antibodies, cardiolipin and β2-glycoprotein 1 in females suffering recurrent pregnancy loss in medellin, Colombia
Original languageSpanish
Pages (from-to)368-375
Number of pages8
JournalRevista Colombiana de Obstetricia y Ginecologia
Volume63
Issue number4
DOIs
StatePublished - 2012
Externally publishedYes

Keywords

  • Annexin AV
  • Antibodies
  • Anticardiolipin antibodies
  • Antiphospholipid antibodies
  • Antiphospholipid syndrome
  • Recurrent abortion

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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