Depressive Symptoms at HIV Testing and Two-Year All-Cause Mortality Among Men Who Inject Drugs in Vietnam

Sara N. Levintow; Brian W. Pence; Tran Viet Ha; Nguyen Le Minh; Teerada Sripaipan; Carl A. Latkin; Pham The Vu; Vu Minh Quan; Constantine Frangakis; Vivian F. Go

doi:10.1007/s10461-018-2318-8

Depressive Symptoms at HIV Testing and Two-Year All-Cause Mortality Among Men Who Inject Drugs in Vietnam

Sara N. Levintow, Brian W. Pence, Tran Viet Ha, Nguyen Le Minh, Teerada Sripaipan, Carl A. Latkin, Pham The Vu, Vu Minh Quan, Constantine Frangakis, Vivian F. Go

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

People who inject drugs (PWID) with HIV experience an elevated risk of death. A potentially important determinant of survival is the high burden of depression. This study examined the relationship of depressive symptoms at HIV testing with 2-year all-cause mortality among newly diagnosed HIV-positive PWID in Vietnam. At HIV testing, 141 PWID (42%) experienced severe depressive symptoms, and over the 2 years following diagnosis, 82 PWID (24%) died. Controlling for potential confounders, the 2-year risk of death among those with depressive symptoms was 9.7% (95% CI − 1.2, 20.6%) higher than the risk among those without depressive symptoms. This increased risk of mortality for PWID with depressive symptoms was relatively consistent throughout the 2-year period: at 6, 12, and 18 months, the risk difference was 12.6% (5.5–19.7%), 13.9% (4.6–23.2%), and 11.0% (0.9–21.1%), respectively. HIV diagnosis may provide an important opportunity for depression screening and treatment, subsequently improving survival in this key population. Trial registry: ClinicalTrials.gov NCT01689545.

Original language	English (US)
Pages (from-to)	609-616
Number of pages	8
Journal	AIDS and behavior
Volume	23
Issue number	3
DOIs	https://doi.org/10.1007/s10461-018-2318-8
State	Published - Mar 15 2019

Keywords

Depression
HIV
Injection drug use
Mortality
Vietnam

ASJC Scopus subject areas

Social Psychology
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1007/s10461-018-2318-8

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title = "Depressive Symptoms at HIV Testing and Two-Year All-Cause Mortality Among Men Who Inject Drugs in Vietnam",

abstract = "People who inject drugs (PWID) with HIV experience an elevated risk of death. A potentially important determinant of survival is the high burden of depression. This study examined the relationship of depressive symptoms at HIV testing with 2-year all-cause mortality among newly diagnosed HIV-positive PWID in Vietnam. At HIV testing, 141 PWID (42%) experienced severe depressive symptoms, and over the 2 years following diagnosis, 82 PWID (24%) died. Controlling for potential confounders, the 2-year risk of death among those with depressive symptoms was 9.7% (95% CI − 1.2, 20.6%) higher than the risk among those without depressive symptoms. This increased risk of mortality for PWID with depressive symptoms was relatively consistent throughout the 2-year period: at 6, 12, and 18 months, the risk difference was 12.6% (5.5–19.7%), 13.9% (4.6–23.2%), and 11.0% (0.9–21.1%), respectively. HIV diagnosis may provide an important opportunity for depression screening and treatment, subsequently improving survival in this key population. Trial registry: ClinicalTrials.gov NCT01689545.",

keywords = "Depression, HIV, Injection drug use, Mortality, Vietnam",

author = "Levintow, {Sara N.} and Pence, {Brian W.} and Ha, {Tran Viet} and {Le Minh}, Nguyen and Teerada Sripaipan and Latkin, {Carl A.} and Vu, {Pham The} and Quan, {Vu Minh} and Constantine Frangakis and Go, {Vivian F.}",

note = "Funding Information: Funding Traineeship support was provided by the National Institute of Allergy and Infectious Diseases (https://www.niaid.nih.gov/): T32 AI070114-10 [SNL]. The parent trial for this study was funded by the National Institute on Drug Abuse (http://www.drugabuse.gov): R01 DA022962-01 [VFG TVH NLM TS CAL PTV VMQ CF]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2018, Springer Science+Business Media, LLC, part of Springer Nature.",

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doi = "10.1007/s10461-018-2318-8",

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T1 - Depressive Symptoms at HIV Testing and Two-Year All-Cause Mortality Among Men Who Inject Drugs in Vietnam

AU - Levintow, Sara N.

AU - Pence, Brian W.

AU - Ha, Tran Viet

AU - Le Minh, Nguyen

AU - Sripaipan, Teerada

AU - Latkin, Carl A.

AU - Vu, Pham The

AU - Quan, Vu Minh

AU - Frangakis, Constantine

AU - Go, Vivian F.

N1 - Funding Information: Funding Traineeship support was provided by the National Institute of Allergy and Infectious Diseases (https://www.niaid.nih.gov/): T32 AI070114-10 [SNL]. The parent trial for this study was funded by the National Institute on Drug Abuse (http://www.drugabuse.gov): R01 DA022962-01 [VFG TVH NLM TS CAL PTV VMQ CF]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2018, Springer Science+Business Media, LLC, part of Springer Nature.

PY - 2019/3/15

Y1 - 2019/3/15

N2 - People who inject drugs (PWID) with HIV experience an elevated risk of death. A potentially important determinant of survival is the high burden of depression. This study examined the relationship of depressive symptoms at HIV testing with 2-year all-cause mortality among newly diagnosed HIV-positive PWID in Vietnam. At HIV testing, 141 PWID (42%) experienced severe depressive symptoms, and over the 2 years following diagnosis, 82 PWID (24%) died. Controlling for potential confounders, the 2-year risk of death among those with depressive symptoms was 9.7% (95% CI − 1.2, 20.6%) higher than the risk among those without depressive symptoms. This increased risk of mortality for PWID with depressive symptoms was relatively consistent throughout the 2-year period: at 6, 12, and 18 months, the risk difference was 12.6% (5.5–19.7%), 13.9% (4.6–23.2%), and 11.0% (0.9–21.1%), respectively. HIV diagnosis may provide an important opportunity for depression screening and treatment, subsequently improving survival in this key population. Trial registry: ClinicalTrials.gov NCT01689545.

AB - People who inject drugs (PWID) with HIV experience an elevated risk of death. A potentially important determinant of survival is the high burden of depression. This study examined the relationship of depressive symptoms at HIV testing with 2-year all-cause mortality among newly diagnosed HIV-positive PWID in Vietnam. At HIV testing, 141 PWID (42%) experienced severe depressive symptoms, and over the 2 years following diagnosis, 82 PWID (24%) died. Controlling for potential confounders, the 2-year risk of death among those with depressive symptoms was 9.7% (95% CI − 1.2, 20.6%) higher than the risk among those without depressive symptoms. This increased risk of mortality for PWID with depressive symptoms was relatively consistent throughout the 2-year period: at 6, 12, and 18 months, the risk difference was 12.6% (5.5–19.7%), 13.9% (4.6–23.2%), and 11.0% (0.9–21.1%), respectively. HIV diagnosis may provide an important opportunity for depression screening and treatment, subsequently improving survival in this key population. Trial registry: ClinicalTrials.gov NCT01689545.

KW - Depression

KW - HIV

KW - Injection drug use

KW - Mortality

KW - Vietnam

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JF - AIDS and behavior

IS - 3

ER -

Depressive Symptoms at HIV Testing and Two-Year All-Cause Mortality Among Men Who Inject Drugs in Vietnam

Abstract

Keywords

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