TY - JOUR
T1 - Depressive symptoms and APOE polymorphisms in an elderly population-based sample
AU - García-Peña, Carmen
AU - Juarez-Cedillo, Teresa
AU - Cruz-Robles, David
AU - Fragoso, José Manuel
AU - Sánchez-García, Sergio
AU - Rodríguez-Pérez, José Manuel
AU - Gallo, Joseph J.
AU - Wagner, Fernando A.
AU - Vargas-Alarcón, Gilberto
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2010/10
Y1 - 2010/10
N2 - AIM: Apolipoprotein E (APOE) has been regarded as the principal susceptibility gene linked with Alzheimer's disease, also suggesting a relationship with depression in the elderly population. Thus, the purpose was to investigate the association of APOE polymorphisms with depression in elderly adults. Methods: APOE polymorphisms were determined in a Mexican population-based sample older than 60 years (n=1566) using 5′ exonuclease TaqMan genotyping assays. Results: The distribution of the APOE allele and genotype frequencies was similar in patients with and without depression. There was no significant association between the presence of alleles or genotypes and depression and anxiety (Short Anxiety Screening Test) considering several combinations of other features. However, patients with the APOE*4 allele presented more thinking and concentration impairment than those patients with the APOE*3 allele. Conclusion: Genetic variation at the APOE gene may contribute to some depressive symptoms in late-onset depression, rather than being a specific risk factor.
AB - AIM: Apolipoprotein E (APOE) has been regarded as the principal susceptibility gene linked with Alzheimer's disease, also suggesting a relationship with depression in the elderly population. Thus, the purpose was to investigate the association of APOE polymorphisms with depression in elderly adults. Methods: APOE polymorphisms were determined in a Mexican population-based sample older than 60 years (n=1566) using 5′ exonuclease TaqMan genotyping assays. Results: The distribution of the APOE allele and genotype frequencies was similar in patients with and without depression. There was no significant association between the presence of alleles or genotypes and depression and anxiety (Short Anxiety Screening Test) considering several combinations of other features. However, patients with the APOE*4 allele presented more thinking and concentration impairment than those patients with the APOE*3 allele. Conclusion: Genetic variation at the APOE gene may contribute to some depressive symptoms in late-onset depression, rather than being a specific risk factor.
KW - apolipoprotein E
KW - depression
KW - depressive symptoms
KW - elderly
KW - genetic susceptibility
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U2 - 10.1097/YPG.0b013e32833a211a
DO - 10.1097/YPG.0b013e32833a211a
M3 - Article
C2 - 20431431
AN - SCOPUS:77957557065
SN - 0955-8829
VL - 20
SP - 215
EP - 220
JO - Psychiatric genetics
JF - Psychiatric genetics
IS - 5
ER -