TY - JOUR
T1 - Dengue Virus (DENV) Neutralizing Antibody Kinetics in Children after Symptomatic Primary and Postprimary DENV Infection
AU - Clapham, Hannah E.
AU - Rodriguez-Barraquer, Isabel
AU - Azman, Andrew S.
AU - Althouse, Benjamin M.
AU - Salje, Henrik
AU - Gibbons, Robert V.
AU - Rothman, Alan L.
AU - Jarman, Richard G.
AU - Nisalak, Ananda
AU - Thaisomboonsuk, Butsaya
AU - Kalayanarooj, Siripen
AU - Nimmannitya, Suchitra
AU - Vaughn, David W.
AU - Green, Sharone
AU - Yoon, In Kyu
AU - Cummings, Derek A.T.
N1 - Funding Information:
This work was supported by the National Institutes of Health (grant P01 AI034533; grant R01 AI102939 to D. A. T. C.) and the US Army Medical Research and Materiel Command.
Publisher Copyright:
© 2015 The Author 2015.
PY - 2016/5/1
Y1 - 2016/5/1
N2 - The immune response to dengue virus (DENV) infection is complex and not fully understood. Using longitudinal data from 181 children with dengue in Thailand who were followed for up to 3 years, we describe neutralizing antibody kinetics following symptomatic DENV infection. We observed that antibody titers varied by serotype, homotypic vs heterotypic responses, and primary versus postprimary infections. The rates of change in antibody titers over time varied between primary and postprimary responses. For primary infections, titers increased from convalescence to 6 months. By comparing homotypic and heterotypic antibody titers, we saw an increase in type specificity from convalescence to 6 months for primary DENV3 infections but not primary DENV1 infections. In postprimary cases, there was a decrease in titers from convalescence up until 6 months after infection. Beginning 1 year after both primary and postprimary infections, there was evidence of increasing antibody titers, with greater increases in children with lower titers, suggesting that antibody titers were boosted due to infection and that higher levels of neutralizing antibody may be more likely to confer a sterilizing immune response. These findings may help to model virus transmission dynamics and provide baseline data to support the development of vaccines and therapeutics.
AB - The immune response to dengue virus (DENV) infection is complex and not fully understood. Using longitudinal data from 181 children with dengue in Thailand who were followed for up to 3 years, we describe neutralizing antibody kinetics following symptomatic DENV infection. We observed that antibody titers varied by serotype, homotypic vs heterotypic responses, and primary versus postprimary infections. The rates of change in antibody titers over time varied between primary and postprimary responses. For primary infections, titers increased from convalescence to 6 months. By comparing homotypic and heterotypic antibody titers, we saw an increase in type specificity from convalescence to 6 months for primary DENV3 infections but not primary DENV1 infections. In postprimary cases, there was a decrease in titers from convalescence up until 6 months after infection. Beginning 1 year after both primary and postprimary infections, there was evidence of increasing antibody titers, with greater increases in children with lower titers, suggesting that antibody titers were boosted due to infection and that higher levels of neutralizing antibody may be more likely to confer a sterilizing immune response. These findings may help to model virus transmission dynamics and provide baseline data to support the development of vaccines and therapeutics.
KW - dengue
KW - longitudinal antibody kinetics
KW - neutralizing antibody
KW - vaccine
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U2 - 10.1093/infdis/jiv759
DO - 10.1093/infdis/jiv759
M3 - Article
C2 - 26704615
AN - SCOPUS:84971614213
SN - 0022-1899
VL - 213
SP - 1428
EP - 1435
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 9
ER -