Denervation and the time course of resting membrane potential changes in skeletal muscle in vivo

Elis F. Stanley; Daniel B. Drachman

doi:10.1016/0014-4886(80)90209-5

Denervation and the time course of resting membrane potential changes in skeletal muscle in vivo

Elis F. Stanley, Daniel B. Drachman

School of Medicine

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The effect of denervation on the skeletal muscle resting membrane potential (RMP) was studied in the soleus muscle of the intact rat. The RMP decreased much later than reported in previous in vitro studies. With a very short nerve stump (less than 2 mm), the RMP began to decrease 18 h after denervation and 4 h after miniature end-plate potentials ceased. With a longer nerve stump (39 to 43 mm) the decrease in RMP was delayed about 3 h. Our findings in vivo fail to confirm previous arguments against a role for acetylcholine in regulating the muscle RMP. The influence of usage and the possible effects of spontaneous quantal and nonquantal acetylcholine release or other hypothetical factors are discussed.

Original language	English (US)
Pages (from-to)	253-259
Number of pages	7
Journal	Experimental Neurology
Volume	69
Issue number	2
DOIs	https://doi.org/10.1016/0014-4886(80)90209-5
State	Published - 1980

Keywords

ACh
MEPP
RMP
acetylcholine
miniature end-plate potential
resting membrane potential

ASJC Scopus subject areas

Neurology
Developmental Neuroscience

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10.1016/0014-4886(80)90209-5

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title = "Denervation and the time course of resting membrane potential changes in skeletal muscle in vivo",

abstract = "The effect of denervation on the skeletal muscle resting membrane potential (RMP) was studied in the soleus muscle of the intact rat. The RMP decreased much later than reported in previous in vitro studies. With a very short nerve stump (less than 2 mm), the RMP began to decrease 18 h after denervation and 4 h after miniature end-plate potentials ceased. With a longer nerve stump (39 to 43 mm) the decrease in RMP was delayed about 3 h. Our findings in vivo fail to confirm previous arguments against a role for acetylcholine in regulating the muscle RMP. The influence of usage and the possible effects of spontaneous quantal and nonquantal acetylcholine release or other hypothetical factors are discussed.",

keywords = "ACh, MEPP, RMP, acetylcholine, miniature end-plate potential, resting membrane potential",

author = "Stanley, {Elis F.} and Drachman, {Daniel B.}",

note = "Funding Information: miniature end-plate potential. {\textquoteright} We thank Dr. A. Pestronk for helpful discussion and C. F. Barlow for preparation of the manuscript. This study was supported by a fellowship grant from the Muscular Dystrophy Association and by the National Institutes of Health grants 5 PO1 NS10920 and 5 ROI HD04817.",

year = "1980",

doi = "10.1016/0014-4886(80)90209-5",

language = "English (US)",

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pages = "253--259",

journal = "Experimental Neurology",

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T1 - Denervation and the time course of resting membrane potential changes in skeletal muscle in vivo

AU - Stanley, Elis F.

AU - Drachman, Daniel B.

N1 - Funding Information: miniature end-plate potential. ’ We thank Dr. A. Pestronk for helpful discussion and C. F. Barlow for preparation of the manuscript. This study was supported by a fellowship grant from the Muscular Dystrophy Association and by the National Institutes of Health grants 5 PO1 NS10920 and 5 ROI HD04817.

PY - 1980

Y1 - 1980

N2 - The effect of denervation on the skeletal muscle resting membrane potential (RMP) was studied in the soleus muscle of the intact rat. The RMP decreased much later than reported in previous in vitro studies. With a very short nerve stump (less than 2 mm), the RMP began to decrease 18 h after denervation and 4 h after miniature end-plate potentials ceased. With a longer nerve stump (39 to 43 mm) the decrease in RMP was delayed about 3 h. Our findings in vivo fail to confirm previous arguments against a role for acetylcholine in regulating the muscle RMP. The influence of usage and the possible effects of spontaneous quantal and nonquantal acetylcholine release or other hypothetical factors are discussed.

AB - The effect of denervation on the skeletal muscle resting membrane potential (RMP) was studied in the soleus muscle of the intact rat. The RMP decreased much later than reported in previous in vitro studies. With a very short nerve stump (less than 2 mm), the RMP began to decrease 18 h after denervation and 4 h after miniature end-plate potentials ceased. With a longer nerve stump (39 to 43 mm) the decrease in RMP was delayed about 3 h. Our findings in vivo fail to confirm previous arguments against a role for acetylcholine in regulating the muscle RMP. The influence of usage and the possible effects of spontaneous quantal and nonquantal acetylcholine release or other hypothetical factors are discussed.

KW - ACh

KW - MEPP

KW - RMP

KW - acetylcholine

KW - miniature end-plate potential

KW - resting membrane potential

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JO - Experimental Neurology

JF - Experimental Neurology

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ER -

Denervation and the time course of resting membrane potential changes in skeletal muscle in vivo

Abstract

Keywords

ASJC Scopus subject areas

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