TY - JOUR
T1 - Dendritic cell factor 1 deletion leads to developmental defects in mushroom-shaped dendritic spines
AU - Zheng, Lili
AU - Liu, Qiang
AU - Wen, Tieqiao
N1 - Funding Information:
This study was supported by the National Science Foundation of China (81271253 and 81471162), the Science and Technology Commission of Shanghai (14JC1402400), and the Key Innovation Project of Shanghai Municipal Education Commission (Grant No. 14ZZ090).
Publisher Copyright:
© 2019 Lippincott Williams and Wilkins. All rights reserved.
PY - 2019
Y1 - 2019
N2 - Dendritic spines are divided into four subtypes, namely, Mushroom, Stubby, Thin, and Branched. The mushroom-shaped spines are related to learning and memory. Previous studies have shown that the dendritic cell factor 1 (Dcf1, a transmembrane protein) affects the memory process and regulates the development of dendritic spines by inhibiting the expression of lipocalin 2 (Lcn2, a member of the family containing over 20 small secreted proteins). However, the exact subtype of dendritic spines that are specifically affected by Dcf1 remains unknown. Here, we identified that deletion of Dcf1 leads to developmental defects in mushroom-shaped spines. We provide evidence for memory defects caused by Dcf1-knockout in mice. We discovered and report for the first time that Dcf1 affects the development of mushroom-shaped spines by inhibiting the expression of Lcn2. Further, we demonstrated that environmental enrichment can effectively stimulate Dcf1-knockout mice and rescue development defects in mushroom-shaped spines caused by Dcf1 deletion. Our results provide a novel direction for further studies on dendritic spine development and mechanisms associated with learning and memory.
AB - Dendritic spines are divided into four subtypes, namely, Mushroom, Stubby, Thin, and Branched. The mushroom-shaped spines are related to learning and memory. Previous studies have shown that the dendritic cell factor 1 (Dcf1, a transmembrane protein) affects the memory process and regulates the development of dendritic spines by inhibiting the expression of lipocalin 2 (Lcn2, a member of the family containing over 20 small secreted proteins). However, the exact subtype of dendritic spines that are specifically affected by Dcf1 remains unknown. Here, we identified that deletion of Dcf1 leads to developmental defects in mushroom-shaped spines. We provide evidence for memory defects caused by Dcf1-knockout in mice. We discovered and report for the first time that Dcf1 affects the development of mushroom-shaped spines by inhibiting the expression of Lcn2. Further, we demonstrated that environmental enrichment can effectively stimulate Dcf1-knockout mice and rescue development defects in mushroom-shaped spines caused by Dcf1 deletion. Our results provide a novel direction for further studies on dendritic spine development and mechanisms associated with learning and memory.
KW - Dcf1
KW - dendritic spines
KW - developmental defects
KW - environmental enrichment
KW - mushroom-shaped spines
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U2 - 10.1097/WNR.0000000000001315
DO - 10.1097/WNR.0000000000001315
M3 - Article
C2 - 31503203
AN - SCOPUS:85079624521
SN - 0959-4965
VL - 30
SP - 1008
EP - 1015
JO - Neuroreport
JF - Neuroreport
IS - 15
ER -