TY - JOUR
T1 - Demographics of sources of HIV-1 transmission in Zambia
T2 - a molecular epidemiology analysis in the HPTN 071 PopART study
AU - HPTN 071 (PopART) Phylogenetics protocol team
AU - PANGEA consortium
AU - Hall, Matthew
AU - Golubchik, Tanya
AU - Bonsall, David
AU - Abeler-Dörner, Lucie
AU - Limbada, Mohammed
AU - Kosloff, Barry
AU - Schaap, Ab
AU - de Cesare, Mariateresa
AU - MacIntyre-Cockett, George
AU - Otecko, Newton
AU - Probert, William
AU - Ratmann, Oliver
AU - Bulas Cruz, Ana
AU - Piwowar-Manning, Estelle
AU - Burns, David N.
AU - Cohen, Myron S.
AU - Donnell, Deborah J.
AU - Eshleman, Susan H.
AU - Simwinga, Musonda
AU - Fidler, Sarah
AU - Hayes, Richard
AU - Ayles, Helen
AU - Fraser, Christophe
AU - Agyei, Yaw
AU - Beyers, Nulda
AU - Bock, Peter
AU - Bond, Virginia
AU - Bwalya, Justin
AU - Cori, Anne
AU - Deventer, Anneen
AU - Dunbar, Rory
AU - El-Sadr, Wafaa
AU - Emel, Lynda
AU - Floyd, Sian
AU - Griffith, Sam
AU - Hargreaves, James
AU - Hauck, Katharina
AU - Headen, Tanette
AU - Hoddinott, Graeme
AU - James, Anelet
AU - Jennings, Karen
AU - Kanema, Sarah
AU - Kruger, James
AU - Kumar, Ramya
AU - Macleod, David
AU - Makola, Nozizwe
AU - Mandla, Nomtha
AU - Moore, Ayana
AU - Grabowski, Kate
AU - Wawer, Maria
N1 - Publisher Copyright:
© 2024 The Author(s)
PY - 2024/1
Y1 - 2024/1
N2 - Background: In the last decade, universally available antiretroviral therapy (ART) has led to greatly improved health and survival of people living with HIV in sub-Saharan Africa, but new infections continue to appear. The design of effective prevention strategies requires the demographic characterisation of individuals acting as sources of infection, which is the aim of this study. Methods: Between 2014 and 2018, the HPTN 071 PopART study was conducted to quantify the public health benefits of ART. Viral samples from 7124 study participants in Zambia were deep-sequenced as part of HPTN 071-02 PopART Phylogenetics, an ancillary study. We used these sequences to identify likely transmission pairs. After demographic weighting of the recipients in these pairs to match the overall HIV-positive population, we analysed the demographic characteristics of the sources to better understand transmission in the general population. Findings: We identified a total of 300 likely transmission pairs. 178 (59·4%) were male to female, with 130 (95% CI 110–150; 43·3%) from males aged 25–40 years. Overall, men transmitted 2·09-fold (2·06–2·29) more infections per capita than women, a ratio peaking at 5·87 (2·78–15·8) in the 35–39 years source age group. 40 (26–57; 13·2%) transmissions linked individuals from different communities in the trial. Of 288 sources with recorded information on drug resistance mutations, 52 (38–69; 18·1%) carried viruses resistant to first-line ART. Interpretation: HIV-1 transmission in the HPTN 071 study communities comes from a wide range of age and sex groups, and there is no outsized contribution to new infections from importation or drug resistance mutations. Men aged 25–39 years, underserved by current treatment and prevention services, should be prioritised for HIV testing and ART. Funding: National Institute of Allergy and Infectious Diseases, US President's Emergency Plan for AIDS Relief, International Initiative for Impact Evaluation, Bill & Melinda Gates Foundation, National Institute on Drug Abuse, and National Institute of Mental Health.
AB - Background: In the last decade, universally available antiretroviral therapy (ART) has led to greatly improved health and survival of people living with HIV in sub-Saharan Africa, but new infections continue to appear. The design of effective prevention strategies requires the demographic characterisation of individuals acting as sources of infection, which is the aim of this study. Methods: Between 2014 and 2018, the HPTN 071 PopART study was conducted to quantify the public health benefits of ART. Viral samples from 7124 study participants in Zambia were deep-sequenced as part of HPTN 071-02 PopART Phylogenetics, an ancillary study. We used these sequences to identify likely transmission pairs. After demographic weighting of the recipients in these pairs to match the overall HIV-positive population, we analysed the demographic characteristics of the sources to better understand transmission in the general population. Findings: We identified a total of 300 likely transmission pairs. 178 (59·4%) were male to female, with 130 (95% CI 110–150; 43·3%) from males aged 25–40 years. Overall, men transmitted 2·09-fold (2·06–2·29) more infections per capita than women, a ratio peaking at 5·87 (2·78–15·8) in the 35–39 years source age group. 40 (26–57; 13·2%) transmissions linked individuals from different communities in the trial. Of 288 sources with recorded information on drug resistance mutations, 52 (38–69; 18·1%) carried viruses resistant to first-line ART. Interpretation: HIV-1 transmission in the HPTN 071 study communities comes from a wide range of age and sex groups, and there is no outsized contribution to new infections from importation or drug resistance mutations. Men aged 25–39 years, underserved by current treatment and prevention services, should be prioritised for HIV testing and ART. Funding: National Institute of Allergy and Infectious Diseases, US President's Emergency Plan for AIDS Relief, International Initiative for Impact Evaluation, Bill & Melinda Gates Foundation, National Institute on Drug Abuse, and National Institute of Mental Health.
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U2 - 10.1016/S2666-5247(23)00220-3
DO - 10.1016/S2666-5247(23)00220-3
M3 - Article
C2 - 38081203
AN - SCOPUS:85182847357
SN - 2666-5247
VL - 5
SP - e62-e71
JO - The Lancet Microbe
JF - The Lancet Microbe
IS - 1
ER -