TY - JOUR
T1 - Dementia of the Alzheimer's type and accelerated aging in Down syndrome.
AU - Devenny, D. A.
AU - Wegiel, J.
AU - Schupf, N.
AU - Jenkins, E.
AU - Zigman, W.
AU - Krinsky-McHale, S. J.
AU - Silverman, W. P.
PY - 2005/4/6
Y1 - 2005/4/6
N2 - This case study, of a woman with Down syndrome and dementia of the Alzheimer's type (DAT), follows the course of her decline over an 11-year period until death at age 57. Detailed neuropathological findings are also presented. This case illustrates features of premature aging that are typically associated with Down syndrome, and the progressive changes in memory and cognition that are usually associated with DAT. Although the subject's cardiovascular condition and thyroid disorder were treated, they may have contributed to the decline of her memory. This case shows the difficulty in diagnosing dementia in an individual with mental retardation who suffered comorbid episodes of depression and psychosis.
AB - This case study, of a woman with Down syndrome and dementia of the Alzheimer's type (DAT), follows the course of her decline over an 11-year period until death at age 57. Detailed neuropathological findings are also presented. This case illustrates features of premature aging that are typically associated with Down syndrome, and the progressive changes in memory and cognition that are usually associated with DAT. Although the subject's cardiovascular condition and thyroid disorder were treated, they may have contributed to the decline of her memory. This case shows the difficulty in diagnosing dementia in an individual with mental retardation who suffered comorbid episodes of depression and psychosis.
UR - http://www.scopus.com/inward/record.url?scp=33644875410&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33644875410&partnerID=8YFLogxK
U2 - 10.1126/sageke.2005.14.dn1
DO - 10.1126/sageke.2005.14.dn1
M3 - Article
C2 - 15814818
AN - SCOPUS:33644875410
SN - 1539-6150
VL - 2005
SP - dn1
JO - Science of aging knowledge environment : SAGE KE
JF - Science of aging knowledge environment : SAGE KE
IS - 14
ER -