TY - JOUR
T1 - Delivery of local therapeutics to the brain
T2 - Working toward advancing treatment for malignant gliomas
AU - Chaichana, Kaisorn L.
AU - Pinheiro, Leon
AU - Brem, Henry
N1 - Publisher Copyright:
© 2015 Future Science Ltd.
PY - 2015/4/1
Y1 - 2015/4/1
N2 - Malignant gliomas, including glioblastoma and anaplastic astrocytomas, are characterized by their propensity to invade surrounding brain parenchyma, making curative resection difficult. These tumors typically recur within two centimeters of the resection cavity even after gross total removal. As a result, there has been an emphasis on developing therapeutics aimed at achieving local disease control. In this review, we will summarize the current developments in the delivery of local therapeutics, namely direct injection, convection-enhanced delivery and implantation of drug-loaded polymers, as well as the application of these therapeutics in future methods including microchip drug delivery and local gene therapy.
AB - Malignant gliomas, including glioblastoma and anaplastic astrocytomas, are characterized by their propensity to invade surrounding brain parenchyma, making curative resection difficult. These tumors typically recur within two centimeters of the resection cavity even after gross total removal. As a result, there has been an emphasis on developing therapeutics aimed at achieving local disease control. In this review, we will summarize the current developments in the delivery of local therapeutics, namely direct injection, convection-enhanced delivery and implantation of drug-loaded polymers, as well as the application of these therapeutics in future methods including microchip drug delivery and local gene therapy.
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U2 - 10.4155/tde.14.114
DO - 10.4155/tde.14.114
M3 - Review article
C2 - 25853310
AN - SCOPUS:84927586584
SN - 2041-5990
VL - 6
SP - 353
EP - 369
JO - Therapeutic Delivery
JF - Therapeutic Delivery
IS - 3
ER -