Deletion of essential functions and tumorigenesis

L. M. De Luca, E. M. McDowell

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The vitamins and their coenzyme role in a variety of metabolic reactions provided an initial impetus upon which modern biochemistry built its foundations. In a similar fashion we believe that investigations into the mode of action of essential nutrients will help pave the way for major advances in our understanding of how tumor cells establish their self-sufficiency. We have recently found that certain tumor cells are deficient in the essential nutrient vitamin A. We will argue that tumor cells arise from carcinogen-initiated cells that have assumed the phenotype of essential-function deficiency.

Original languageEnglish (US)
Pages (from-to)2064-2065
Number of pages2
JournalJournal of Nutrition
Issue number10
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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