Deletion mapping of the regions with AMELY from two Chinese males

Jianhui Xie, Chengchen Shao, Hongmei Xu, Wei Zhu, Zhiping Liu, Qiqun Tang, Yueqin Zhou

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The amelogenin (AMEL) is widely used in many multiplex PCR kits for gender determination. However, the null of amelogenin Y (AMELY) can result in the incorrect genotyping of male samples as females. In this study, we report the deletion of AMELY in two cases with a deletion frequency of 0.019% (2/10526) in our laboratory. The deletion region with AMELY was mapped by using other twelve loci, which shows the class I deletion pattern. Further, the Y chromosome short tandem repeat (Y-STR) typing shows that these two cases share the same haplotype with other two cases from previous reports. The haplogroup of the two cases was predicted as O3 haplogroup with a 100% probability. Altogether, this study will provide evidence to further demonstrate the deletion of AMELY in Chinese population.

Original languageEnglish (US)
Pages (from-to)290-292
Number of pages3
JournalLegal Medicine
Issue number5
StatePublished - 2014
Externally publishedYes


  • AMEL
  • Chinese population
  • Deletion
  • DYS458
  • Haplogroup

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Issues, ethics and legal aspects
  • Medicine(all)


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