Delayed-type hypersensitivity and cell-mediated immunity in the pathogenesis of tuberculosis

Arthur M. Dannenberg

Research output: Contribution to journalReview articlepeer-review

226 Scopus citations


It is widely believed that cell-mediated immunity and the associated ability of macrophages to destroy or inhibit the bacillus are all that is required to control pulmonary tuberculosis. However, although cell-mediated immunity is a major host defense against the tubercle bacillus, it is fully effective only in one of the four stages of the disease. Here, Arthur Dannenberg describes the entire pathogenesis of tuberculosis, with illustrations from the rabbit model of M.B. Lurie. In addition, he documents that the delayed-type hypersensitivity reaction (producing tissue necrosis) greatly benefits the host by arresting the logarithmic growth of bacilli within immature macrophages.

Original languageEnglish (US)
Pages (from-to)228-233
Number of pages6
JournalImmunology Today
Issue number7
StatePublished - Jul 1991
Externally publishedYes

ASJC Scopus subject areas

  • Immunology


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