TY - JOUR
T1 - Delayed-type hypersensitivity and cell-mediated immunity in the pathogenesis of tuberculosis
AU - Dannenberg, Arthur M.
N1 - Funding Information:
The author appreciates the superb editorial assistance of Ilse M. Harrop, and the financial support of the Johns Hopkins Environmental Health Sciences Center Grant ES-03819, from the National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina and grant HL-10342 from National Heart, Lung and Blood Institute, Bethesda, Maryland.
PY - 1991/7
Y1 - 1991/7
N2 - It is widely believed that cell-mediated immunity and the associated ability of macrophages to destroy or inhibit the bacillus are all that is required to control pulmonary tuberculosis. However, although cell-mediated immunity is a major host defense against the tubercle bacillus, it is fully effective only in one of the four stages of the disease. Here, Arthur Dannenberg describes the entire pathogenesis of tuberculosis, with illustrations from the rabbit model of M.B. Lurie. In addition, he documents that the delayed-type hypersensitivity reaction (producing tissue necrosis) greatly benefits the host by arresting the logarithmic growth of bacilli within immature macrophages.
AB - It is widely believed that cell-mediated immunity and the associated ability of macrophages to destroy or inhibit the bacillus are all that is required to control pulmonary tuberculosis. However, although cell-mediated immunity is a major host defense against the tubercle bacillus, it is fully effective only in one of the four stages of the disease. Here, Arthur Dannenberg describes the entire pathogenesis of tuberculosis, with illustrations from the rabbit model of M.B. Lurie. In addition, he documents that the delayed-type hypersensitivity reaction (producing tissue necrosis) greatly benefits the host by arresting the logarithmic growth of bacilli within immature macrophages.
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U2 - 10.1016/0167-5699(91)90035-R
DO - 10.1016/0167-5699(91)90035-R
M3 - Review article
C2 - 1822092
AN - SCOPUS:0025793687
SN - 1471-4906
VL - 12
SP - 228
EP - 233
JO - Trends in Immunology
JF - Trends in Immunology
IS - 7
ER -