TY - JOUR
T1 - Dehydroepiandrosterone secretion in healthy older men and women
T2 - Effects of testosterone and growth hormone administration in older men
AU - Muniyappa, Ranganath
AU - Wong, Kelli A.
AU - Baldwin, Howard L.
AU - Sorkin, John D.
AU - Johnson, Michael L.
AU - Bhasin, Shalender
AU - Harman, S. Mitchell
AU - Blackman, Marc R.
N1 - Funding Information:
This work was supported by the Intramural Research Programs of the National Center for Complementary and Alternative Medicine and National Institute on Aging, National Institutes of Health, Bethesda and Baltimore, MD, and by National Institutes of Health Research Grants RO-1 AG11005 (to M.R.B.); RO-1 RRO19991 and R25 DK064122 (to M.L.J.); R0-1 AG14369 (to S.B.); General Clinical Research Center Grant MO-1-RR-02719 from the National Center for Research Resources, National Institutes of Health, Bethesda, MD; and by the National Institute on Aging Claude D. Pepper Older Americans Independence Center (P60-AG12583) at the University of Maryland, Department of Veterans Affairs and Veterans Affairs Medical Center, Baltimore Geriatric Research, Education and Clinical Center (GRECC), and the National Institute of Diabetes and Digestive and Kidney Diseases Clinical Nutrition Research Unit of Maryland (NIH P30 DK072488).
PY - 2006/11
Y1 - 2006/11
N2 - Context: Aging is associated with diminished gonadal steroid and GH/IGF-I axis activity; whether these changes contribute to the parallel declines of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) production is unknown, as are the effects of sex steroid and/or GH administration on DHEA and DHEAS production. Objective: Our objective was to evaluate morning DHEAS concentrations and nocturnal DHEA secretory dynamics in healthy older men and women, before and after chronic administration of sex steroid(s) alone, GH alone, sex steroid(s) combined with GH, or placebo alone. Design: We compared nocturnal DHEA secretory dynamics (2000 h to 0800 h, sampling every 20 min, analyzed by multiparameter deconvolution and approximate entropy algorithms) in healthy older (65-88 yr) men (n = 68) and women (n = 36), both before and after 26 wk of administration of sex steroid(s) alone [testosterone (T) in men or estrogen/progesterone in women], GH alone, sex steroid(s) combined with GH, or placebo alone. Results: Morning concentrations of DHEAS were lower; nocturnal DHEA pulsatile production rate, burst frequency, and amplitude were higher; and half-life was shorter in women (P < 0.05). Nocturnal integrated DHEA concentrations, total production rate, and approximate entropy did not differ significantly by sex. Because of small treatment group sizes in women, only hormone intervention results in men are presented. In men, T and T plus GH administration significantly decreased nocturnal integrated DHEA but not morning DHEAS concentrations. GH alone exerted no significant effects on nocturnal DHEA secretion or morning DHEAS. Conclusions: Spontaneous nocturnal DHEA secretion is sexually dimorphic in healthy older individuals, and T administration decreases nocturnal DHEA secretion in older men. The clinical significance of sex steroid modulation of DHEA secretion in older persons remains to be elucidated.
AB - Context: Aging is associated with diminished gonadal steroid and GH/IGF-I axis activity; whether these changes contribute to the parallel declines of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS) production is unknown, as are the effects of sex steroid and/or GH administration on DHEA and DHEAS production. Objective: Our objective was to evaluate morning DHEAS concentrations and nocturnal DHEA secretory dynamics in healthy older men and women, before and after chronic administration of sex steroid(s) alone, GH alone, sex steroid(s) combined with GH, or placebo alone. Design: We compared nocturnal DHEA secretory dynamics (2000 h to 0800 h, sampling every 20 min, analyzed by multiparameter deconvolution and approximate entropy algorithms) in healthy older (65-88 yr) men (n = 68) and women (n = 36), both before and after 26 wk of administration of sex steroid(s) alone [testosterone (T) in men or estrogen/progesterone in women], GH alone, sex steroid(s) combined with GH, or placebo alone. Results: Morning concentrations of DHEAS were lower; nocturnal DHEA pulsatile production rate, burst frequency, and amplitude were higher; and half-life was shorter in women (P < 0.05). Nocturnal integrated DHEA concentrations, total production rate, and approximate entropy did not differ significantly by sex. Because of small treatment group sizes in women, only hormone intervention results in men are presented. In men, T and T plus GH administration significantly decreased nocturnal integrated DHEA but not morning DHEAS concentrations. GH alone exerted no significant effects on nocturnal DHEA secretion or morning DHEAS. Conclusions: Spontaneous nocturnal DHEA secretion is sexually dimorphic in healthy older individuals, and T administration decreases nocturnal DHEA secretion in older men. The clinical significance of sex steroid modulation of DHEA secretion in older persons remains to be elucidated.
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U2 - 10.1210/jc.2006-0867
DO - 10.1210/jc.2006-0867
M3 - Article
C2 - 16926252
AN - SCOPUS:33751529740
SN - 0021-972X
VL - 91
SP - 4445
EP - 4452
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 11
ER -