Deformable medical image registration: A survey

Aristeidis Sotiras, Christos Davatzikos, Nikos Paragios

Research output: Contribution to journalArticlepeer-review

801 Scopus citations


Deformable image registration is a fundamental task in medical image processing. Among its most important applications, one may cite: 1) multi-modality fusion, where information acquired by different imaging devices or protocols is fused to facilitate diagnosis and treatment planning; 2) longitudinal studies, where temporal structural or anatomical changes are investigated; and 3) population modeling and statistical atlases used to study normal anatomical variability. In this paper, we attempt to give an overview of deformable registration methods, putting emphasis on the most recent advances in the domain. Additional emphasis has been given to techniques applied to medical images. In order to study image registration methods in depth, their main components are identified and studied independently. The most recent techniques are presented in a systematic fashion. The contribution of this paper is to provide an extensive account of registration techniques in a systematic manner.

Original languageEnglish (US)
Article number6522524
Pages (from-to)1153-1190
Number of pages38
JournalIEEE transactions on medical imaging
Issue number7
StatePublished - 2013
Externally publishedYes


  • Bibliographical review
  • deformable registration
  • medical image analysis

ASJC Scopus subject areas

  • Software
  • Radiological and Ultrasound Technology
  • Computer Science Applications
  • Electrical and Electronic Engineering


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