Defining esophageal landmarks, gastroesophageal reflux disease, and Barrett's esophagus

Kenneth Devault, Barry P. Mcmahon, Altay Celebi, Guido Costamagna, Michele Marchese, John O. Clarke, Reza A. Hejazi, Richard W. Mccallum, Vincenzo Savarino, Patrizia Zentilin, Edoardo Savarino, Mike Thomson, Rhonda F. Souza, Claire L. Donohoe, Naoimh J. O'Farrell, John V. Reynolds

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


The following paper on gastroesophageal reflux disease (GERD) and Barrett's esophagus (BE) includes commentaries on defining esophageal landmarks; new techniques for evaluating upper esophageal sphincter (UES) tone; differential diagnosis of GERD, BE, and hiatal hernia (HH); the use of high-resolution manometry for evaluation of reflux; the role of fundic relaxation in reflux; the use of 24-h esophageal pH-impedance testing in differentiating acid from nonacid reflux and its potential inclusion in future Rome criteria; classification of endoscopic findings in GERD; the search for the cell origin that generates BE; and the relationship between BE, Barrett's carcinoma, and obesity.

Original languageEnglish (US)
Pages (from-to)278-295
Number of pages18
JournalAnnals of the New York Academy of Sciences
Issue number1
StatePublished - Oct 2013
Externally publishedYes


  • Dysphagia
  • Endoscopy
  • GERD
  • Manometry
  • NERD

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • History and Philosophy of Science


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