Defective antigen-induced lymphocyte proliferation in the X-linked hyper-IgM syndrome

R. Ameratunga; H. M. Lederman; K. E. Sullivan; H. D. Ochs; K. Seyama; J. K. French; R. Prestidge; J. Marbrook; W. C. Fanslow; J. A. Winkelstein

doi:10.1016/S0022-3476(97)70139-2

Defective antigen-induced lymphocyte proliferation in the X-linked hyper-IgM syndrome

R. Ameratunga, H. M. Lederman, K. E. Sullivan, H. D. Ochs, K. Seyama, J. K. French, R. Prestidge, J. Marbrook, W. C. Fanslow, J. A. Winkelstein

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45 Scopus citations

Abstract

We examined T-cell proliferation in five patients with X-linked hyper- IgM syndrome (XHIM), using a panel of antigens and lectins. All patients had impaired antigen-induced proliferation, whereas their lectin responses were normal. Thus, in addition to severely depressed antibody responses, patients with XHIM have a defect in antigen-specific T-cell proliferation, which may explain their susceptibility to pathogens such as Pneumocystis carinii.

Original language	English (US)
Pages (from-to)	147-150
Number of pages	4
Journal	Journal of Pediatrics
Volume	131
Issue number	1 I
DOIs	https://doi.org/10.1016/S0022-3476(97)70139-2
State	Published - 1997

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1016/S0022-3476(97)70139-2

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abstract = "We examined T-cell proliferation in five patients with X-linked hyper- IgM syndrome (XHIM), using a panel of antigens and lectins. All patients had impaired antigen-induced proliferation, whereas their lectin responses were normal. Thus, in addition to severely depressed antibody responses, patients with XHIM have a defect in antigen-specific T-cell proliferation, which may explain their susceptibility to pathogens such as Pneumocystis carinii.",

author = "R. Ameratunga and Lederman, {H. M.} and Sullivan, {K. E.} and Ochs, {H. D.} and K. Seyama and French, {J. K.} and R. Prestidge and J. Marbrook and Fanslow, {W. C.} and Winkelstein, {J. A.}",

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AU - Ameratunga, R.

AU - Lederman, H. M.

AU - Sullivan, K. E.

AU - Ochs, H. D.

AU - Seyama, K.

AU - French, J. K.

AU - Prestidge, R.

AU - Marbrook, J.

AU - Fanslow, W. C.

AU - Winkelstein, J. A.

PY - 1997

Y1 - 1997

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AB - We examined T-cell proliferation in five patients with X-linked hyper- IgM syndrome (XHIM), using a panel of antigens and lectins. All patients had impaired antigen-induced proliferation, whereas their lectin responses were normal. Thus, in addition to severely depressed antibody responses, patients with XHIM have a defect in antigen-specific T-cell proliferation, which may explain their susceptibility to pathogens such as Pneumocystis carinii.

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JO - Journal of Pediatrics

JF - Journal of Pediatrics

IS - 1 I

ER -

Defective antigen-induced lymphocyte proliferation in the X-linked hyper-IgM syndrome

Abstract

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