We examined T-cell proliferation in five patients with X-linked hyper- IgM syndrome (XHIM), using a panel of antigens and lectins. All patients had impaired antigen-induced proliferation, whereas their lectin responses were normal. Thus, in addition to severely depressed antibody responses, patients with XHIM have a defect in antigen-specific T-cell proliferation, which may explain their susceptibility to pathogens such as Pneumocystis carinii.
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health