Defective antigen-induced lymphocyte proliferation in the X-linked hyper-IgM syndrome

R. Ameratunga, H. M. Lederman, K. E. Sullivan, H. D. Ochs, K. Seyama, J. K. French, R. Prestidge, J. Marbrook, W. C. Fanslow, J. A. Winkelstein

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


We examined T-cell proliferation in five patients with X-linked hyper- IgM syndrome (XHIM), using a panel of antigens and lectins. All patients had impaired antigen-induced proliferation, whereas their lectin responses were normal. Thus, in addition to severely depressed antibody responses, patients with XHIM have a defect in antigen-specific T-cell proliferation, which may explain their susceptibility to pathogens such as Pneumocystis carinii.

Original languageEnglish (US)
Pages (from-to)147-150
Number of pages4
JournalJournal of Pediatrics
Issue number1 I
StatePublished - 1997

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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