TY - JOUR
T1 - Deep learning for automatic volumetric segmentation of left ventricular myocardium and ischaemic scar from multi-slice late gadolinium enhancement cardiovascular magnetic resonance
AU - Jani, Vivek P.
AU - Ostovaneh, Mohammad
AU - Chamera, Elzbieta
AU - Kato, Yoko
AU - Lima, Joao A.C.
AU - Ambale-Venkatesh, Bharath
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/6/1
Y1 - 2024/6/1
N2 - Aims This study details application of deep learning for automatic volumetric segmentation of left ventricular (LV) myocardium and scar and automated quantification of myocardial ischaemic scar burden from late gadolinium enhancement cardiovascular magnetic resonance (LGE-CMR). Methods We included 501 images and manual segmentations of short-axis LGE-CMR from over 20 multinational sites, from which and results 377 studies were used for training and 124 studies from unique participants for internal validation. A third test set of 52 images was used for external evaluation. Three models, U-Net, Cascaded U-Net, and U-Net++, were trained with a novel adaptive weighted categorical cross-entropy loss function. Model performance was evaluated using concordance correlation coefficients (CCCs) for LV mass and per cent myocardial scar burden. Cascaded U-Net was found to be the best model for the quantification of LV mass and scar percentage. The model exhibited a mean difference of −5 ± 23 g for LV mass, −0.4 ± 11.2 g for scar mass, and −0.8 ± 7% for per cent scar. CCC were 0.87, 0.77, and 0.78 for LV mass, scar mass, and per cent scar burden, respectively, in the internal validation set and 0.75, 0.71, and 0.69, respectively, in the external test set. For segmental scar mass, CCC was 0.74 for apical scar, 0.91 for mid-ventricular scar, and 0.73 for basal scar, demonstrating moderate to strong agreement. Conclusion We successfully trained a convolutional neural network for volumetric segmentation and analysis of LV scar burden from LGE-CMR images in a large, multinational cohort of participants with ischaemic scar.
AB - Aims This study details application of deep learning for automatic volumetric segmentation of left ventricular (LV) myocardium and scar and automated quantification of myocardial ischaemic scar burden from late gadolinium enhancement cardiovascular magnetic resonance (LGE-CMR). Methods We included 501 images and manual segmentations of short-axis LGE-CMR from over 20 multinational sites, from which and results 377 studies were used for training and 124 studies from unique participants for internal validation. A third test set of 52 images was used for external evaluation. Three models, U-Net, Cascaded U-Net, and U-Net++, were trained with a novel adaptive weighted categorical cross-entropy loss function. Model performance was evaluated using concordance correlation coefficients (CCCs) for LV mass and per cent myocardial scar burden. Cascaded U-Net was found to be the best model for the quantification of LV mass and scar percentage. The model exhibited a mean difference of −5 ± 23 g for LV mass, −0.4 ± 11.2 g for scar mass, and −0.8 ± 7% for per cent scar. CCC were 0.87, 0.77, and 0.78 for LV mass, scar mass, and per cent scar burden, respectively, in the internal validation set and 0.75, 0.71, and 0.69, respectively, in the external test set. For segmental scar mass, CCC was 0.74 for apical scar, 0.91 for mid-ventricular scar, and 0.73 for basal scar, demonstrating moderate to strong agreement. Conclusion We successfully trained a convolutional neural network for volumetric segmentation and analysis of LV scar burden from LGE-CMR images in a large, multinational cohort of participants with ischaemic scar.
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U2 - 10.1093/ehjci/jeae022
DO - 10.1093/ehjci/jeae022
M3 - Article
C2 - 38244222
AN - SCOPUS:85195060099
SN - 2047-2404
VL - 25
SP - 829
EP - 838
JO - European heart journal cardiovascular Imaging
JF - European heart journal cardiovascular Imaging
IS - 6
ER -