Deep inspiration-induced changes in lung volume decrease with severity of asthma

Nicola Scichilone, Roberto Marchese, Simona Soresi, Amelia Interrante, Alkis Togias, Vincenzo Bellia

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


We have previously reported that the magnitude of deep inspiration (DI)-induced bronchodilation is only slightly reduced in mild asthmatics, compared to healthy subjects. The aim of this study was to evaluate whether increased severity of asthma is associated with impairment in the ability of DI to induce changes in lung volume. Thirty-six consecutive asthmatics recruited from the Pulmonary and the Allergy Outpatient Clinics of the Institute of Respiratory Diseases of the University of Palermo were divided into 3 groups: Intermittent (I), Mild Persistent (MP) and Moderate-Severe (MS), based on GINA guidelines. Single dose methacholine (Mch) bronchoprovocations were performed in the absence of DI, to induce at least 15% reduction in inspiratory vital capacity (IVC) from baseline. The post-Mch IVC was followed by 4 consecutive DI and by another IVC, to determine the bronchodilatory effect of DI. The bronchodilatory effect of DI was found to significantly decrease with increasing severity of asthma (I: 68±5.4%, MP: 45±7.2%, MS: 4±15.6%; ANOVA: P<0.0001). Bronchodilation by DI, but not FEV1 or FEV1/FVC, was also inversely correlated to symptom scores (r = - 0.42, P = 0.01) and to weekly salbutamol usage (r = - 0.47, P = 0.004). These observations provide support to the hypothesis that the attenuation of the bronchodilatory effect of DI contributes to the severity of the clinical manifestations of asthma.

Original languageEnglish (US)
Pages (from-to)951-956
Number of pages6
JournalRespiratory Medicine
Issue number5
StatePublished - May 2007
Externally publishedYes


  • Asthma
  • Bronchodilation
  • Corticosteroids
  • Lung inflation
  • Methacholine

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


Dive into the research topics of 'Deep inspiration-induced changes in lung volume decrease with severity of asthma'. Together they form a unique fingerprint.

Cite this