Dedicated small field of view SPECT system based on a 5 PSPMT and crystal scintillator array for high resolution small animal cardiac imaging

R. Wojcik; A. R. Goode; M. F. Smith; G. A. Beller; P. I. Ellman; S. Majewski; Y. J. Qi; B. M.W. Tsui; Y. Wang; A. G. Weisenberger; D. K. Glover

doi:10.1109/nssmic.2003.1352232

Dedicated small field of view SPECT system based on a 5 PSPMT and crystal scintillator array for high resolution small animal cardiac imaging

R. Wojcik, A. R. Goode, M. F. Smith, G. A. Beller, P. I. Ellman, S. Majewski, Y. J. Qi, B. M.W. Tsui, Y. Wang, A. G. Weisenberger, D. K. Glover

School of Medicine

Research output: Contribution to journal › Conference article › peer-review

1 Scopus citations

Abstract

We have developed and evaluated a high resolution small animal single photon emission computed tomography (SPECT) imaging system using a small field-of-view gamma camera based on a 10 cm diameter Hamamatsu R3292 position sensitive PMT and Nal(TI) crystal array. The instrument was designed primarily to image myocardial perfusion as well as heart and lung uptake of molecular-targeted tracers in rodent models. In the present study, we evaluated the system performance by imaging a stationary micro SPECT phantom and a variety of in vivo small animal models. Using a magnification factor of 1.57 and a 0.5mm pinhole collimator, the reconstructed phantom images showed a spatial separation of individual rods as small as 1.6 mm. A myocardial perfusion study which was performed on a rat yielded high quality tomographic slices of the heart which clearly revealed both left and right ventricular walls and chambers. Such high resolution cardiac imaging was made possible due to the high intrinsic spatial resolution of the detector combined with pinhole collimation and OSEM reconstruction methodology. The system proved to be a very useful tool for use in molecular imaging of targeted probes.

Original language	English (US)
Article number	M3-43
Pages (from-to)	1819-1823
Number of pages	5
Journal	IEEE Nuclear Science Symposium Conference Record
Volume	3
DOIs	https://doi.org/10.1109/nssmic.2003.1352232
State	Published - 2003
Event	2003 IEEE Nuclear Science Symposium Conference Record - Nuclear Science Symposium, Medical Imaging Conference - Portland, OR, United States Duration: Oct 19 2003 → Oct 25 2003

ASJC Scopus subject areas

Radiation
Nuclear and High Energy Physics
Radiology Nuclear Medicine and imaging

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Wojcik, R., Goode, A. R., Smith, M. F., Beller, G. A., Ellman, P. I., Majewski, S., Qi, Y. J., Tsui, B. M. W., Wang, Y., Weisenberger, A. G., & Glover, D. K. (2003). Dedicated small field of view SPECT system based on a 5 PSPMT and crystal scintillator array for high resolution small animal cardiac imaging. IEEE Nuclear Science Symposium Conference Record, 3, 1819-1823. Article M3-43. https://doi.org/10.1109/nssmic.2003.1352232

Wojcik, R, Goode, AR, Smith, MF, Beller, GA, Ellman, PI, Majewski, S, Qi, YJ, Tsui, BMW, Wang, Y, Weisenberger, AG & Glover, DK 2003, 'Dedicated small field of view SPECT system based on a 5 PSPMT and crystal scintillator array for high resolution small animal cardiac imaging', IEEE Nuclear Science Symposium Conference Record, vol. 3, M3-43, pp. 1819-1823. https://doi.org/10.1109/nssmic.2003.1352232

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title = "Dedicated small field of view SPECT system based on a 5 PSPMT and crystal scintillator array for high resolution small animal cardiac imaging",

abstract = "We have developed and evaluated a high resolution small animal single photon emission computed tomography (SPECT) imaging system using a small field-of-view gamma camera based on a 10 cm diameter Hamamatsu R3292 position sensitive PMT and Nal(TI) crystal array. The instrument was designed primarily to image myocardial perfusion as well as heart and lung uptake of molecular-targeted tracers in rodent models. In the present study, we evaluated the system performance by imaging a stationary micro SPECT phantom and a variety of in vivo small animal models. Using a magnification factor of 1.57 and a 0.5mm pinhole collimator, the reconstructed phantom images showed a spatial separation of individual rods as small as 1.6 mm. A myocardial perfusion study which was performed on a rat yielded high quality tomographic slices of the heart which clearly revealed both left and right ventricular walls and chambers. Such high resolution cardiac imaging was made possible due to the high intrinsic spatial resolution of the detector combined with pinhole collimation and OSEM reconstruction methodology. The system proved to be a very useful tool for use in molecular imaging of targeted probes.",

author = "R. Wojcik and Goode, {A. R.} and Smith, {M. F.} and Beller, {G. A.} and Ellman, {P. I.} and S. Majewski and Qi, {Y. J.} and Tsui, {B. M.W.} and Y. Wang and Weisenberger, {A. G.} and Glover, {D. K.}",

year = "2003",

doi = "10.1109/nssmic.2003.1352232",

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AU - Beller, G. A.

AU - Ellman, P. I.

AU - Majewski, S.

AU - Qi, Y. J.

AU - Tsui, B. M.W.

AU - Wang, Y.

AU - Weisenberger, A. G.

AU - Glover, D. K.

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N2 - We have developed and evaluated a high resolution small animal single photon emission computed tomography (SPECT) imaging system using a small field-of-view gamma camera based on a 10 cm diameter Hamamatsu R3292 position sensitive PMT and Nal(TI) crystal array. The instrument was designed primarily to image myocardial perfusion as well as heart and lung uptake of molecular-targeted tracers in rodent models. In the present study, we evaluated the system performance by imaging a stationary micro SPECT phantom and a variety of in vivo small animal models. Using a magnification factor of 1.57 and a 0.5mm pinhole collimator, the reconstructed phantom images showed a spatial separation of individual rods as small as 1.6 mm. A myocardial perfusion study which was performed on a rat yielded high quality tomographic slices of the heart which clearly revealed both left and right ventricular walls and chambers. Such high resolution cardiac imaging was made possible due to the high intrinsic spatial resolution of the detector combined with pinhole collimation and OSEM reconstruction methodology. The system proved to be a very useful tool for use in molecular imaging of targeted probes.

AB - We have developed and evaluated a high resolution small animal single photon emission computed tomography (SPECT) imaging system using a small field-of-view gamma camera based on a 10 cm diameter Hamamatsu R3292 position sensitive PMT and Nal(TI) crystal array. The instrument was designed primarily to image myocardial perfusion as well as heart and lung uptake of molecular-targeted tracers in rodent models. In the present study, we evaluated the system performance by imaging a stationary micro SPECT phantom and a variety of in vivo small animal models. Using a magnification factor of 1.57 and a 0.5mm pinhole collimator, the reconstructed phantom images showed a spatial separation of individual rods as small as 1.6 mm. A myocardial perfusion study which was performed on a rat yielded high quality tomographic slices of the heart which clearly revealed both left and right ventricular walls and chambers. Such high resolution cardiac imaging was made possible due to the high intrinsic spatial resolution of the detector combined with pinhole collimation and OSEM reconstruction methodology. The system proved to be a very useful tool for use in molecular imaging of targeted probes.

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Dedicated small field of view SPECT system based on a 5 PSPMT and crystal scintillator array for high resolution small animal cardiac imaging

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