Abstract
Background: High prevalences of reduced glomerular filtration rate (GFR) have been reported from HIV-infected individuals in sub-Saharan Africa when initiating antiretroviral therapy. However little is known about natural history HIV-related kidney disease or about background rates of reduced GFR in HIV-negative individuals in this region. Methods: We estimated GFR from first and last available stored serum samples from 1202 HIV-infected and 664 age-matched and sex-matched HIV-negative individuals in a community-based cohort of HIV-infected and HIV-negative individuals in Rakai, Uganda, between 1994 and 2003. We assessed the prevalence and incidence of mildly (60-89 ml•min•1.73 m) and moderately (<60 ml•min•1.73 m) reduced GFR using standard analytical methods. Results: At baseline, 8.4% of HIV-infected and 4.7% of HIV-negative individuals had mildly or moderately reduced GFR (P = 0.002). During follow-up, the rates of decline to a lower GFR category were of 32.4 and 20.3 per 1000 person-years in HIV-infected and HIV-negative subjects, respectively (P = 0.019). Conclusions: In an unselected community sample of HIV-infected individuals followed in Rakai, Uganda, before the availability of antiretroviral therapy, the prevalence of decreased GFR and the incidence of a decline in GFR category during follow-up were both significantly higher in HIV-infected subjects compared with HIV-negative subjects, although moderately reduced GFR was uncommon.
Original language | English (US) |
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Pages (from-to) | 491-494 |
Number of pages | 4 |
Journal | Journal of Acquired Immune Deficiency Syndromes |
Volume | 55 |
Issue number | 4 |
DOIs | |
State | Published - Dec 1 2010 |
Keywords
- Africa
- HIV infection
- Uganda
- chronic kidney disease
- cohort study
ASJC Scopus subject areas
- Infectious Diseases
- Pharmacology (medical)