Decreased hippocampal muscarinic cholinergic receptor binding measured by 123I‐iododexetimide and single‐photon emission computed tomography in epilepsy

Hans W. Müller‐Gärtner; Helen S. Mayberg; Robert S. Fisher; Ronald P. Lesser; Alan A. Wilson; Hayden T. Ravert; Robert F. Dannals; Henry N. Wagner; Sumio Uematsu; J. James Frost

doi:10.1002/ana.410340221

Decreased hippocampal muscarinic cholinergic receptor binding measured by ¹²³I‐iododexetimide and single‐photon emission computed tomography in epilepsy

Hans W. Müller‐Gärtner, Helen S. Mayberg, Robert S. Fisher, Ronald P. Lesser, Alan A. Wilson, Hayden T. Ravert, Robert F. Dannals, Henry N. Wagner, Sumio Uematsu, J. James Frost

School of Medicine

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Regional binding of ¹²³I‐iododexetimide, a muscarinic acetylchline receptor antagonist, was measured in vivo in the temporal lobes of 4 patients with complex partial seizures using single‐photon emissions computed tomography. In the anterior hippocampus ipsilateral to the electrical focus, ¹²³I‐iododexetimide binding was decreased by 40 ± 9% (mean 7plusmn; SD, p <0.01) compared with the contralateral hippocampus; ¹²³I‐iododexetimide binding in other temporal lobe regions was symmetrical. The data indicate a regionally specific change of muscarinic acetylcholine receptor in anterior hippocampus in complex partial seizures of temporal lobe origin.

Original language	English (US)
Pages (from-to)	235-238
Number of pages	4
Journal	Annals of neurology
Volume	34
Issue number	2
DOIs	https://doi.org/10.1002/ana.410340221
State	Published - Aug 1993

ASJC Scopus subject areas

Neurology
Clinical Neurology

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Müller‐Gärtner, H. W., Mayberg, H. S., Fisher, R. S., Lesser, R. P., Wilson, A. A., Ravert, H. T., Dannals, R. F., Wagner, H. N., Uematsu, S., & Frost, J. J. (1993). Decreased hippocampal muscarinic cholinergic receptor binding measured by ¹²³I‐iododexetimide and single‐photon emission computed tomography in epilepsy. Annals of neurology, 34(2), 235-238. https://doi.org/10.1002/ana.410340221

Müller‐Gärtner, HW, Mayberg, HS, Fisher, RS, Lesser, RP, Wilson, AA, Ravert, HT, Dannals, RF, Wagner, HN, Uematsu, S & Frost, JJ 1993, 'Decreased hippocampal muscarinic cholinergic receptor binding measured by ¹²³I‐iododexetimide and single‐photon emission computed tomography in epilepsy', Annals of neurology, vol. 34, no. 2, pp. 235-238. https://doi.org/10.1002/ana.410340221

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title = "Decreased hippocampal muscarinic cholinergic receptor binding measured by 123I‐iododexetimide and single‐photon emission computed tomography in epilepsy",

abstract = "Regional binding of 123I‐iododexetimide, a muscarinic acetylchline receptor antagonist, was measured in vivo in the temporal lobes of 4 patients with complex partial seizures using single‐photon emissions computed tomography. In the anterior hippocampus ipsilateral to the electrical focus, 123I‐iododexetimide binding was decreased by 40 ± 9% (mean 7plusmn; SD, p <0.01) compared with the contralateral hippocampus; 123I‐iododexetimide binding in other temporal lobe regions was symmetrical. The data indicate a regionally specific change of muscarinic acetylcholine receptor in anterior hippocampus in complex partial seizures of temporal lobe origin.",

author = "M{\"u}ller‐G{\"a}rtner, {Hans W.} and Mayberg, {Helen S.} and Fisher, {Robert S.} and Lesser, {Ronald P.} and Wilson, {Alan A.} and Ravert, {Hayden T.} and Dannals, {Robert F.} and Wagner, {Henry N.} and Sumio Uematsu and Frost, {J. James}",

year = "1993",

month = aug,

doi = "10.1002/ana.410340221",

language = "English (US)",

volume = "34",

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AU - Müller‐Gärtner, Hans W.

AU - Mayberg, Helen S.

AU - Fisher, Robert S.

AU - Lesser, Ronald P.

AU - Wilson, Alan A.

AU - Ravert, Hayden T.

AU - Dannals, Robert F.

AU - Wagner, Henry N.

AU - Uematsu, Sumio

AU - Frost, J. James

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AB - Regional binding of 123I‐iododexetimide, a muscarinic acetylchline receptor antagonist, was measured in vivo in the temporal lobes of 4 patients with complex partial seizures using single‐photon emissions computed tomography. In the anterior hippocampus ipsilateral to the electrical focus, 123I‐iododexetimide binding was decreased by 40 ± 9% (mean 7plusmn; SD, p <0.01) compared with the contralateral hippocampus; 123I‐iododexetimide binding in other temporal lobe regions was symmetrical. The data indicate a regionally specific change of muscarinic acetylcholine receptor in anterior hippocampus in complex partial seizures of temporal lobe origin.

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Decreased hippocampal muscarinic cholinergic receptor binding measured by ¹²³I‐iododexetimide and single‐photon emission computed tomography in epilepsy

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