Decreased frontal lobe ratio of N-acetyl aspartate to choline in familial schizophrenia: a proton magnetic resonance spectroscopy study

Wolfgang Block; Thomas A. Bayer; Ralf Tepest; Frank Träber; Marcella Rietschel; Daniel J. Müller; Thomas G. Schulze; William G. Honer; Wolfgang Maier; Hans H. Schild; Peter Falkai

doi:10.1016/S0304-3940(00)01264-7

Decreased frontal lobe ratio of N-acetyl aspartate to choline in familial schizophrenia: a proton magnetic resonance spectroscopy study

Wolfgang Block, Thomas A. Bayer, Ralf Tepest, Frank Träber, Marcella Rietschel, Daniel J. Müller, Thomas G. Schulze, William G. Honer, Wolfgang Maier, Hans H. Schild, Peter Falkai

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Abstract

Neuropathological and neuroimaging studies suggest neuronal dysfunction in schizophrenia. N-acetyl aspartate (NAA) is a useful marker of neuronal dysfunction that can be measured with magnetic resonance spectroscopy (MRS). In the present study NAA, choline (Cho), phospho-creatine ((P)Cr), inositol containing compounds and glutamine/glutamate (Glx) were assessed in the left frontal lobe and basal ganglia of subjects with familial schizophrenia, family members with mixed psychiatric diagnoses, unaffected family members, and community controls. Concentrations of metabolites were analyzed and expressed as ratios. NAA/Cho, NAA/(P)Cr and Glx containing compounds showed a negative correlation with age in the frontal lobe. After covarying for age, subjects with schizophrenia had a significant reduction in the left frontal lobe NAA/Cho ratio compared with unaffected family members (P=0.018) as well as with community non-familial (P=0.037) controls. These MRS observations support the hypothesis of a disease-related neuronal deficit in the frontal lobe of schizophrenic patients, and relatively normal basal ganglia. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original language	English (US)
Pages (from-to)	147-151
Number of pages	5
Journal	Neuroscience Letters
Volume	289
Issue number	2
DOIs	https://doi.org/10.1016/S0304-3940(00)01264-7
State	Published - Aug 4 2000
Externally published	Yes

Keywords

Basal ganglia
Frontal lobe
Magnetic resonance spectroscopy
Neurochemistry
Schizophrenia

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0304-3940(00)01264-7

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Block, W., Bayer, T. A., Tepest, R., Träber, F., Rietschel, M., Müller, D. J., Schulze, T. G., Honer, W. G., Maier, W., Schild, H. H., & Falkai, P. (2000). Decreased frontal lobe ratio of N-acetyl aspartate to choline in familial schizophrenia: a proton magnetic resonance spectroscopy study. Neuroscience Letters, 289(2), 147-151. https://doi.org/10.1016/S0304-3940(00)01264-7

Block, W, Bayer, TA, Tepest, R, Träber, F, Rietschel, M, Müller, DJ, Schulze, TG, Honer, WG, Maier, W, Schild, HH & Falkai, P 2000, 'Decreased frontal lobe ratio of N-acetyl aspartate to choline in familial schizophrenia: a proton magnetic resonance spectroscopy study', Neuroscience Letters, vol. 289, no. 2, pp. 147-151. https://doi.org/10.1016/S0304-3940(00)01264-7

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title = "Decreased frontal lobe ratio of N-acetyl aspartate to choline in familial schizophrenia: a proton magnetic resonance spectroscopy study",

abstract = "Neuropathological and neuroimaging studies suggest neuronal dysfunction in schizophrenia. N-acetyl aspartate (NAA) is a useful marker of neuronal dysfunction that can be measured with magnetic resonance spectroscopy (MRS). In the present study NAA, choline (Cho), phospho-creatine ((P)Cr), inositol containing compounds and glutamine/glutamate (Glx) were assessed in the left frontal lobe and basal ganglia of subjects with familial schizophrenia, family members with mixed psychiatric diagnoses, unaffected family members, and community controls. Concentrations of metabolites were analyzed and expressed as ratios. NAA/Cho, NAA/(P)Cr and Glx containing compounds showed a negative correlation with age in the frontal lobe. After covarying for age, subjects with schizophrenia had a significant reduction in the left frontal lobe NAA/Cho ratio compared with unaffected family members (P=0.018) as well as with community non-familial (P=0.037) controls. These MRS observations support the hypothesis of a disease-related neuronal deficit in the frontal lobe of schizophrenic patients, and relatively normal basal ganglia. Copyright (C) 2000 Elsevier Science Ireland Ltd.",

keywords = "Basal ganglia, Frontal lobe, Magnetic resonance spectroscopy, Neurochemistry, Schizophrenia",

author = "Wolfgang Block and Bayer, {Thomas A.} and Ralf Tepest and Frank Tr{\"a}ber and Marcella Rietschel and M{\"u}ller, {Daniel J.} and Schulze, {Thomas G.} and Honer, {William G.} and Wolfgang Maier and Schild, {Hans H.} and Peter Falkai",

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doi = "10.1016/S0304-3940(00)01264-7",

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T2 - a proton magnetic resonance spectroscopy study

AU - Block, Wolfgang

AU - Bayer, Thomas A.

AU - Tepest, Ralf

AU - Träber, Frank

AU - Rietschel, Marcella

AU - Müller, Daniel J.

AU - Schulze, Thomas G.

AU - Honer, William G.

AU - Maier, Wolfgang

AU - Schild, Hans H.

AU - Falkai, Peter

PY - 2000/8/4

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N2 - Neuropathological and neuroimaging studies suggest neuronal dysfunction in schizophrenia. N-acetyl aspartate (NAA) is a useful marker of neuronal dysfunction that can be measured with magnetic resonance spectroscopy (MRS). In the present study NAA, choline (Cho), phospho-creatine ((P)Cr), inositol containing compounds and glutamine/glutamate (Glx) were assessed in the left frontal lobe and basal ganglia of subjects with familial schizophrenia, family members with mixed psychiatric diagnoses, unaffected family members, and community controls. Concentrations of metabolites were analyzed and expressed as ratios. NAA/Cho, NAA/(P)Cr and Glx containing compounds showed a negative correlation with age in the frontal lobe. After covarying for age, subjects with schizophrenia had a significant reduction in the left frontal lobe NAA/Cho ratio compared with unaffected family members (P=0.018) as well as with community non-familial (P=0.037) controls. These MRS observations support the hypothesis of a disease-related neuronal deficit in the frontal lobe of schizophrenic patients, and relatively normal basal ganglia. Copyright (C) 2000 Elsevier Science Ireland Ltd.

AB - Neuropathological and neuroimaging studies suggest neuronal dysfunction in schizophrenia. N-acetyl aspartate (NAA) is a useful marker of neuronal dysfunction that can be measured with magnetic resonance spectroscopy (MRS). In the present study NAA, choline (Cho), phospho-creatine ((P)Cr), inositol containing compounds and glutamine/glutamate (Glx) were assessed in the left frontal lobe and basal ganglia of subjects with familial schizophrenia, family members with mixed psychiatric diagnoses, unaffected family members, and community controls. Concentrations of metabolites were analyzed and expressed as ratios. NAA/Cho, NAA/(P)Cr and Glx containing compounds showed a negative correlation with age in the frontal lobe. After covarying for age, subjects with schizophrenia had a significant reduction in the left frontal lobe NAA/Cho ratio compared with unaffected family members (P=0.018) as well as with community non-familial (P=0.037) controls. These MRS observations support the hypothesis of a disease-related neuronal deficit in the frontal lobe of schizophrenic patients, and relatively normal basal ganglia. Copyright (C) 2000 Elsevier Science Ireland Ltd.

KW - Basal ganglia

KW - Frontal lobe

KW - Magnetic resonance spectroscopy

KW - Neurochemistry

KW - Schizophrenia

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Decreased frontal lobe ratio of N-acetyl aspartate to choline in familial schizophrenia: a proton magnetic resonance spectroscopy study

Abstract

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