Abstract
Reaction Time (RT) is associated with increased amplitude of the Blood Oxygen-Level Dependent (BOLD) response in task positive regions. Few studies have focused on whether opposing RT-related suppression of task activity also occurs. The current study used two Go/No-go tasks with different cognitive demands to examine regions that showed greater BOLD suppression for longer RT trials. These RT-related suppression effects occurred within the DMN and were task-specific, localizing to separate regions for the two tasks. In the task requiring working memory, RT-related de-coupling of the DMN occurred. This was reflected by opposing RT-BOLD effects for different DMN regions, as well as by reduced positive RT-related Psycho-Physiological Interaction (PPI) connectivity within the DMN and a lack of negative RT-related PPI connectivity between DMN and task positive regions. The results suggest that RT-related DMN suppression is task-specific. RT-related de-coupling of the DMN with more complex task demands may contribute to lapses of attention and performance decrements that occur during cognitively-demanding tasks.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 666-676 |
| Number of pages | 11 |
| Journal | Brain Imaging and Behavior |
| Volume | 11 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jun 1 2017 |
Keywords
- Anti-correlation
- Attention
- Default mode network
- Reaction times
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Neurology
- Clinical Neurology
- Cognitive Neuroscience
- Cellular and Molecular Neuroscience
- Psychiatry and Mental health
- Behavioral Neuroscience