Decline of Vaccine-Induced Antipneumococcal Antibody in Children With Nephrotic Syndrome

John S. Spika, Neal A. Halsey, Chap T. Le, Alfred J. Fish, Gary M. Lum, Brian A. Lauer, Gerald Schiffman, G. Scott Giebink

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Twenty-five children with steroid-responsive idiopathic nephrotic syndrome were studied for persistence of antipneumococcal capsular polysaccharide antibody during relapse of their disease and at 1, 6, and 12 months after vaccination with the 14-valent pneumococcal vaccine. Nonrelapsers (group I) were compared to those who had at least one relapse but whose sera were obtained during remission (group II). Group II had a more rapid decline in total anticapsular antibody per month than group I (5.3% v 2.4%). Analysis by individual anticapsular types showed that differences between groups approached significance only for type 4 (P = .07). Rates of decline of antibody against pneumococcal capsular polysaccharide varied among types. One year after vaccination, 50% of patients had < 300 ngAbN/mL against types 4, 6A, 7F 8, and 19F Sera obtained from seven patients during relapse had geometric mean antibody concentrations < 300 ngAbN/mL against those same types; two of these types have been reported to cause disease in vaccinated patients with nephrosis. Decline of antibody against pneumococcal capsular polysaccharide following vaccination varies by capsular type. Type-specific analysis should be used when monitoring serum antibody levels in these patients after vaccination.

Original languageEnglish (US)
Pages (from-to)466-470
Number of pages5
JournalAmerican Journal of Kidney Diseases
Issue number6
StatePublished - 1986
Externally publishedYes


  • Pneumococcal
  • antibody
  • nephrotic syndrome
  • vaccination

ASJC Scopus subject areas

  • Nephrology


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