Decay-Accelerating Factor

Joseph M. Christy, Christopher B. Toomey, David M. Cauvi, Kenneth M. Pollard

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


CD55 or decay-accelerating factor (DAF) is a 70. kDa glycoprotein consisting of four complement control protein (CCP) domains with a single N-linked glycosylation site between CCP1 and 2, a heavily O-glycosylated membrane proximal domain rich in serine, threonine and proline and a glycosylphosphatidylinositol (GPI) anchor. DAF is present on most cell types and intrinsically functions to protect the host cell from autologous complement attack by preventing the formation and accelerating the decay of the classical and alternative C3 and C5 convertases. DAF deficiency is linked to several diseases including paroxysmal nocturnal haemoglobinuria, as well as autoimmune diseases.

Original languageEnglish (US)
Title of host publicationThe Complement FactsBook
Subtitle of host publicationSecond Edition
Number of pages10
ISBN (Print)9780128104200
StatePublished - 2018
Externally publishedYes


  • CD55
  • Decay-accelerating factor (DAF)
  • Paroxysmal nocturnal haemoglobinuria

ASJC Scopus subject areas

  • General Immunology and Microbiology


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