Decatenation of kinetoplast DNA by topoisomerases.

J. C. Marini, K. G. Miller, P. T. Englund

Research output: Contribution to journalArticlepeer-review

130 Scopus citations


Kinetoplast DNA is the mitochondrial DNA of trypanosomatids such as Crithidia fasciculata. This DNA is in the form of networks containing thousands of DNA circles which are apparently catenated (interlocked). Some topoisomerases, such as T4 phage topoisomerase and DNA gyrase, catalyze a decatenation of the networks to form individual covalently closed circles.

Original languageEnglish (US)
Pages (from-to)4976-4979
Number of pages4
JournalJournal of Biological Chemistry
Issue number11
StatePublished - Jun 10 1980
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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