TY - JOUR
T1 - Death after acute myocardial infarction
T2 - Interrelation between left ventricular dysfunction, arrhythmias and ischemia
AU - Gottlieb, Sheldon H.
AU - Ouyang, Pamela
AU - Gottlieb, Sidney O.
N1 - Funding Information:
From the Division of Cardiology, Department of Medicine, The Francis Scott Key Medical Center, The Johns Hopkins Medical Institutions, Baltimore, Maryland. This study was supported in part by the National Heart, Lung, and Blood Institute SCOR Grant 17655-13 and in part by the General Clinical Research Center, Francis Scott Key Medical Center, Branch 5-MOl-RR02719 from The National Institutes of Health, Division of Research Resources, Bethesda, Maryland. Address for reprints: Sheldon H. Gottlieb, MD, Division of Cardiology, Francis Scott Key Medical Center, 4940 Eastern Avenue, Baltimore, Maryland 21224.
PY - 1988/1/29
Y1 - 1988/1/29
N2 - Patients who survive an acute myocardial infarction face an increased risk of sudden death for approximately 6 months after hospital discharge; their prognosis is determined by the severity of their coronary arteriosclerosis and the degree of left ventricular dysfunction. Frequent ventricular premature complexes and evidence of ischemia either spontaneously or on treadmill are also markers for early morbidity and mortality in patients who are discharged from the hospital after acute myocardial infarction. The degree of left ventricular dysfunction is the strongest predictor of mortality; patients who have both left ventricular dysfunction, frequent premature ventricular beats and evidence of ischemia are at the highest risk of mortality after hospital discharge. It appears likely that all 3 of these risk factors interact and that therapy to reduce morbidity and mortality after myocardial infarction should aim at the amelioration of each of these risk factors. A model for the interaction of these risk factors is proposed and an approach to treatment for patients at high risk of mortality after hospital discharge after myocardial infarction is suggested.
AB - Patients who survive an acute myocardial infarction face an increased risk of sudden death for approximately 6 months after hospital discharge; their prognosis is determined by the severity of their coronary arteriosclerosis and the degree of left ventricular dysfunction. Frequent ventricular premature complexes and evidence of ischemia either spontaneously or on treadmill are also markers for early morbidity and mortality in patients who are discharged from the hospital after acute myocardial infarction. The degree of left ventricular dysfunction is the strongest predictor of mortality; patients who have both left ventricular dysfunction, frequent premature ventricular beats and evidence of ischemia are at the highest risk of mortality after hospital discharge. It appears likely that all 3 of these risk factors interact and that therapy to reduce morbidity and mortality after myocardial infarction should aim at the amelioration of each of these risk factors. A model for the interaction of these risk factors is proposed and an approach to treatment for patients at high risk of mortality after hospital discharge after myocardial infarction is suggested.
UR - http://www.scopus.com/inward/record.url?scp=0023808781&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023808781&partnerID=8YFLogxK
U2 - 10.1016/0002-9149(88)91348-3
DO - 10.1016/0002-9149(88)91348-3
M3 - Article
C2 - 3277365
AN - SCOPUS:0023808781
SN - 0002-9149
VL - 61
SP - 7
EP - 12
JO - The American journal of cardiology
JF - The American journal of cardiology
IS - 3
ER -