De novo development of a cavernous malformation of the brain: Significance of factors with paracrine and endocrine activity: Case report

Wolf Lüdemann, Verena Ellerkamp, Alexandru C. Stan, Sami Hussein, Issam A. Awad, Richard E. Clatterbuck, Daniele Rigamonti

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

OBJECTIVE AND IMPORTANCE: De novo development of cavernous malformations is poorly documented in the literature. CLINICAL PRESENTATION: We report the case of a 37-year old woman with de novo growth of a cavernous malformation of the brain. The patient presented with a 12-month history of nonspecific headaches and paresthesias after two pregnancies. After computed tomographic scanning of the cranium, a cavernous malformation located parieto-occipitally within the right brain hemisphere was diagnosed. Control magnetic resonance imaging scans obtained 12 years earlier did not reveal a similar lesion. INTERVENTION: Surgery was performed, and the specimen was analyzed histopathologically. CONCLUSION: Immunohistochemistry demonstrated lack of expression of pituitary hormones as well as of androgen, estrogen, and progesterone hormone receptors. However, strong expression of both basic fibroblast growth factor and CD44 was detected in surrounding tissue, and expression of CD44 was noted within the matrix of the cavernous malformation.

Original languageEnglish (US)
Pages (from-to)646-650
Number of pages5
JournalNeurosurgery
Volume50
Issue number3
DOIs
StatePublished - Mar 1 2002

Keywords

  • Cavernous malformation
  • Growth factor

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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