DDS promotes longevity through a microbiome-mediated starvation signal

Haeri Choi, Sung Chun Cho, Young Wan Ha, Billie Ocampo, Shirley Park, Shiwen Chen, Christopher F. Bennett, Jeehae Han, Ryan Rossner, Jong Sun Kang, Yun ll Lee, Sang Chul Park, Matt Kaeberlein

Research output: Contribution to journalArticlepeer-review


The antibiotic diaminodiphenyl sulfone (DDS) is used in combination with other antibiotics as a first line treatment for leprosy. DDS has been previously reported to extend lifespan in Caenorhabditis elegans through inhibition of pyruvate kinase and decreased mitochondrial function. Here we report an alternative mechanism of action by which DDS promotes longevity in C. elegans by reducing folate production by the microbiome. This results in altered methionine cycle metabolite levels mimicking the effects of metformin and lifespan extension that is dependent on the starvation- and hypoxia-induced flavin containing monoxygenase, FMO-2.

Original languageEnglish (US)
Pages (from-to)64-69
Number of pages6
JournalTranslational Medicine of Aging
StatePublished - 2019
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Aging
  • Geriatrics and Gerontology
  • Clinical Neurology
  • Cell Biology


Dive into the research topics of 'DDS promotes longevity through a microbiome-mediated starvation signal'. Together they form a unique fingerprint.

Cite this