DDS promotes longevity through a microbiome-mediated starvation signal

Haeri Choi; Sung Chun Cho; Young Wan Ha; Billie Ocampo; Shirley Park; Shiwen Chen; Christopher F. Bennett; Jeehae Han; Ryan Rossner; Jong Sun Kang; Yun ll Lee; Sang Chul Park; Matt Kaeberlein

doi:10.1016/j.tma.2019.07.001

DDS promotes longevity through a microbiome-mediated starvation signal

Haeri Choi, Sung Chun Cho, Young Wan Ha, Billie Ocampo, Shirley Park, Shiwen Chen, Christopher F. Bennett, Jeehae Han, Ryan Rossner, Jong Sun Kang, Yun ll Lee, Sang Chul Park, Matt Kaeberlein

Research output: Contribution to journal › Article › peer-review

Abstract

The antibiotic diaminodiphenyl sulfone (DDS) is used in combination with other antibiotics as a first line treatment for leprosy. DDS has been previously reported to extend lifespan in Caenorhabditis elegans through inhibition of pyruvate kinase and decreased mitochondrial function. Here we report an alternative mechanism of action by which DDS promotes longevity in C. elegans by reducing folate production by the microbiome. This results in altered methionine cycle metabolite levels mimicking the effects of metformin and lifespan extension that is dependent on the starvation- and hypoxia-induced flavin containing monoxygenase, FMO-2.

Original language	English (US)
Pages (from-to)	64-69
Number of pages	6
Journal	Translational Medicine of Aging
Volume	3
DOIs	https://doi.org/10.1016/j.tma.2019.07.001
State	Published - 2019
Externally published	Yes

ASJC Scopus subject areas

Physiology
Aging
Geriatrics and Gerontology
Clinical Neurology
Cell Biology

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10.1016/j.tma.2019.07.001

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title = "DDS promotes longevity through a microbiome-mediated starvation signal",

abstract = "The antibiotic diaminodiphenyl sulfone (DDS) is used in combination with other antibiotics as a first line treatment for leprosy. DDS has been previously reported to extend lifespan in Caenorhabditis elegans through inhibition of pyruvate kinase and decreased mitochondrial function. Here we report an alternative mechanism of action by which DDS promotes longevity in C. elegans by reducing folate production by the microbiome. This results in altered methionine cycle metabolite levels mimicking the effects of metformin and lifespan extension that is dependent on the starvation- and hypoxia-induced flavin containing monoxygenase, FMO-2.",

author = "Haeri Choi and Cho, {Sung Chun} and Ha, {Young Wan} and Billie Ocampo and Shirley Park and Shiwen Chen and Bennett, {Christopher F.} and Jeehae Han and Ryan Rossner and Kang, {Jong Sun} and Lee, {Yun ll} and Park, {Sang Chul} and Matt Kaeberlein",

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year = "2019",

doi = "10.1016/j.tma.2019.07.001",

language = "English (US)",

volume = "3",

pages = "64--69",

journal = "Translational Medicine of Aging",

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TY - JOUR

T1 - DDS promotes longevity through a microbiome-mediated starvation signal

AU - Choi, Haeri

AU - Cho, Sung Chun

AU - Ha, Young Wan

AU - Ocampo, Billie

AU - Park, Shirley

AU - Chen, Shiwen

AU - Bennett, Christopher F.

AU - Han, Jeehae

AU - Rossner, Ryan

AU - Kang, Jong Sun

AU - Lee, Yun ll

AU - Park, Sang Chul

AU - Kaeberlein, Matt

PY - 2019

Y1 - 2019

N2 - The antibiotic diaminodiphenyl sulfone (DDS) is used in combination with other antibiotics as a first line treatment for leprosy. DDS has been previously reported to extend lifespan in Caenorhabditis elegans through inhibition of pyruvate kinase and decreased mitochondrial function. Here we report an alternative mechanism of action by which DDS promotes longevity in C. elegans by reducing folate production by the microbiome. This results in altered methionine cycle metabolite levels mimicking the effects of metformin and lifespan extension that is dependent on the starvation- and hypoxia-induced flavin containing monoxygenase, FMO-2.

AB - The antibiotic diaminodiphenyl sulfone (DDS) is used in combination with other antibiotics as a first line treatment for leprosy. DDS has been previously reported to extend lifespan in Caenorhabditis elegans through inhibition of pyruvate kinase and decreased mitochondrial function. Here we report an alternative mechanism of action by which DDS promotes longevity in C. elegans by reducing folate production by the microbiome. This results in altered methionine cycle metabolite levels mimicking the effects of metformin and lifespan extension that is dependent on the starvation- and hypoxia-induced flavin containing monoxygenase, FMO-2.

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DO - 10.1016/j.tma.2019.07.001

M3 - Article

AN - SCOPUS:85081110141

SN - 2468-5011

VL - 3

SP - 64

EP - 69

JO - Translational Medicine of Aging

JF - Translational Medicine of Aging

ER -

DDS promotes longevity through a microbiome-mediated starvation signal

Abstract

ASJC Scopus subject areas

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