Darwinian evolution in the genealogy of haemoglobin

Morris Goodman, G. William Moore, Genji Matsuda

Research output: Contribution to journalArticlepeer-review

221 Scopus citations


Frequencies of mutations between reconstructed ancestor and descendant sequences of codons for metazoan globin chains show that natural selection guided protein evolution. Mutations which improved haemoglobin function were accepted at an accelerated rate in the first vertebrates. Rates decelerated after functional opportunities had been exploited.

Original languageEnglish (US)
Pages (from-to)603-608
Number of pages6
Issue number5493
StatePublished - 1975
Externally publishedYes

ASJC Scopus subject areas

  • General


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